On the use of ibotenic acid to lesion selectively different components of the hippocampal formation.

Journal of Neuroscience Methods
L E Jarrard

Abstract

Procedures are described for lesioning two components of the hippocampal formation (hippocampus, subiculum) using multiple injections of small amounts of ibotenic acid (IBO). The resulting loss of cells is more selective and limited than can be obtained with conventional techniques. Thus, problems associated with damage to adjacent areas, fibers-of-passage, and damage to the vasculature are minimized. The results of behavioral experiments indicate that the effects of IBO lesions of the hippocampus are more subtle than those found with conventional lesion techniques. The general approach of using multiple injections of small amounts of neurotoxins can be used to selectively lesion other components of the hippocampal formation.

References

May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R B Goldschmidt, O Steward

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Citations

Nov 24, 1999·Hippocampus·H MaaswinkelI Q Whishaw
Mar 23, 2001·Hippocampus·S G AnagnostarasM S Fanselow
Jul 9, 2002·Hippocampus·Leonard E Jarrard
Aug 31, 2002·Hippocampus·Stephan G AnagnostarasMichael S Fanselow
Jan 10, 2009·Brain Structure & Function·Margriet J Dolleman-van der WeelMenno P Witter
Jan 15, 1996·Brain Research·P J MebergA Routtenberg
Mar 1, 1994·Physiology & Behavior·N A SchmajukB A Christiansen
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·B K LipskaD R Weinberger
Nov 1, 1991·Behavioral and Neural Biology·M M'HarziJ Delacour
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Mar 1, 1993·Behavioral and Neural Biology·T L Davidson, L E Jarrard
Nov 1, 1995·Behavioural Brain Research·L E Jarrard
May 19, 2000·Neuroscience and Biobehavioral Reviews·M Colombo, N Broadbent
May 14, 1998·Neuroscience and Biobehavioral Reviews·I Q Whishaw
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·M P McDonald, J B Overmier
Dec 7, 2002·Journal of Neuroscience Methods·Sarah NemanicJocelyne Bachevalier
Feb 13, 2001·Behavioural Brain Research·K H ChanT L Davidson
Nov 24, 2001·Behavioural Brain Research·A L TracyT L Davidson
May 9, 2002·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Jun 6, 2002·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Nov 14, 2002·Behavioural Brain Research·Elisabeth W P M DaenenJan M Van Ree
Mar 19, 2003·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Mar 19, 2003·Behavioural Brain Research·D M BannermanJ N P Rawlins

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