On the use of tranquillisers in epilepsy

Epilepsia
Michael R Trimble

Abstract

In this article, the use of benzodiazepines (BZDs) in epilepsy is reviewed. In particular, it concentrates on the use of oral BZDs, and, following a brief discussion as to their value in psychiatric disorders generally, their more specific use in epilepsy is then noted. The main oral drugs are the 1,4BZDs and 1,5-BZDs. The latter is represented only by clobazam (CLB), and the advantages of the 1,5-BZDs over the 1,4-BZDs are reviewed. It is concluded that CLB has a significant value in a number of situations. It is a first-line add-on therapy when standard medications have failed. It is useful in patients that have catamenial seizures, clusters of seizures, and also in the prevention of postictal syndromes. It is used in childhood epilepsy, and is also helpful in the management of febrile seizures.

References

Oct 12, 1978·The New England Journal of Medicine·T R Browne
Jul 1, 1988·Epilepsy Research·A J HellerE H Reynolds

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Citations

Sep 13, 2002·NMR in Biomedicine
Aug 6, 2003·Epilepsy & Behavior : E&B·Marco Mula, Michael R Trimble
Mar 1, 2003·Epilepsy & Behavior : E&B·Kenneth R. AlperAntoaneta J. Balabanov
Apr 2, 2009·Neuropsychiatric Disease and Treatment·Kenou van Rijckevorsel
Mar 8, 2007·Expert Review of Neurotherapeutics·Line Sveberg Røste, Erik Taubøll
Mar 1, 2016·Current Treatment Options in Neurology·Juan G Ochoa, William A Kilgo
Apr 4, 2008·Acta Neurologica Scandinavica·J RissS Collins
Sep 29, 2011·CNS Neuroscience & Therapeutics·Peter Wolf
Apr 2, 2004·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Ricardo GuarnieriAmérico Ceiki Sakamoto

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