On the Variation of Water Diffusion Coefficient in Stratum Corneum With Water Content

Journal of Pharmaceutical Sciences
Xin LiGerald B Kasting

Abstract

Water permeability and transient water sorption data in human and porcine stratum corneum (SC) are analyzed in conjunction with equilibrium water sorption data and a dynamic skin swelling model to develop a quantitative model for water diffusivity in the SC as a function of its water content. The recommended function (model 1) is phenomenological and treats the SC as a uniform, swellable slab. This approach yields satisfactory agreement with experimental data over a wide range of RH and associated equilibrium SC water content, Cw. It is supported by two alternative approaches. Model 2 considers the SC to be a multilaminate membrane consisting of alternating lipid and protein layers. Diffusivity in the protein phase is estimated from water diffusivity in other keratinized tissues, whereas diffusivity in the lipid phase is assumed to be linearly related to the swelling strain on intercellular lipids. Model 3 uses an analysis previously suggested by Stockdale to rationalize transepidermal water loss data in humans over a wide range of relative humidity. All models yield similar results for 0.20 ≤ Cw ≤ 0.78 g/cm(3), the usual range of SC water content in vivo.

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Citations

May 21, 2016·Frontiers in Psychology·David L Barack, Michael L Platt
Aug 28, 2016·International Journal of Cosmetic Science·S A Ventura, G B Kasting
Oct 23, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Sachie Kudo, Satoru Nakashima
Jul 11, 2018·Journal of Biophotonics·Qiushuo SunEmma Pickwell-MacPherson
Dec 4, 2016·American Journal of Clinical Dermatology·Julia K GittlerSeth J Orlow
Dec 24, 2017·Journal of Pharmaceutical Sciences·Chandana KodiweeraAnnette L Bunge
Aug 30, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Rattanavalai NitiyaromWanee Wisuthsarewong

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