On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations

Frontiers in Neurology
Samantha WuJames Giordano

Abstract

Central neurotrauma, such as spinal cord injury or traumatic brain injury, can damage critical axonal pathways and neurons and lead to partial to complete loss of neural function that is difficult to address in the mature central nervous system. Improvement and innovation in the development, manufacture, and delivery of stem-cell based therapies, as well as the continued exploration of newer forms of stem cells, have allowed the professional and public spheres to resolve technical and ethical questions that previously hindered stem cell research for central nervous system injury. Recent in vitro and in vivo models have demonstrated the potential that reprogrammed autologous stem cells, in particular, have to restore functionality and induce regeneration-while potentially mitigating technical issues of immunogenicity, rejection, and ethical issues of embryonic derivation. These newer stem-cell based approaches are not, however, without concerns and problems of safety, efficacy, use and distribution. This review is an assessment of the current state of the science, the potential solutions that have been and are currently being explored, and the problems and questions that arise from what appears to be a promising way forward (i.e...Continue Reading

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Citations

Oct 28, 2019·Current Stem Cell Research & Therapy·Mehdi ForouzeshSeyed Esmaeil Khoshnam
Oct 13, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shuhei KobashiHideto Kojima
Apr 9, 2021·Expert Opinion on Biological Therapy·William Brett McIntyreMichael G Fehlings

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Methods Mentioned

BETA
biopsy
histone acetylation
biopsies
transfection

Clinical Trials Mentioned

NCT02302157
NCT01772810
NCT01321333
NCT03296618
NCT02688049
NCT02326662
NCT02687672
NCT03505034
NCT01676441
NCT02481440

Software Mentioned

NeuroRegen

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