On translational regulation and EMT

Seminars in Cancer Biology
Valentina EvdokimovaPoul H B Sorensen

Abstract

Translational regulation is increasingly recognized as a critical mediator of gene expression. It endows cells with the ability to decide when a particular protein is expressed, thereby ensuring proper and prompt cellular responses to environmental cues. This ability to reprogram protein synthesis and to permit the translation of the respective regulatory messages is particularly important in complex changing environments, including embryonic development, wound healing and environmental stress. Not surprisingly, mistakes in this process can lead to cancer. This review will focus on the mechanisms of translational control operating in normal and cancer cells. We discuss the possibility that progression of primary epithelial tumors into a motile mesenchymal-like phenotype during the invasive phase of metastasis is driven, in part, by a switch from cap-dependent to cap-independent translation.

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Citations

Aug 15, 2014·PloS One·Dmitry N LyabinLev P Ovchinnikov
Apr 24, 2015·The Journal of Pathology·Simon GreletBéatrice Nawrocki-Raby
Jan 4, 2013·PloS One·George S HusseyPhilip H Howe
Feb 6, 2017·Biochemical and Biophysical Research Communications·Panpan XiongFei Liu
Jan 3, 2018·The Journal of Pathology·Amal M El-Naggar, Poul H Sorensen
Nov 2, 2018·Bioscience, Biotechnology, and Biochemistry·Yujiao TangEun-Kyung Kim
May 10, 2019·Nature Communications·Varsha PrakashC Theresa Vincent
Jul 21, 2020·RNA Biology·Gunhild Sommer, Tilman Heise
Jul 30, 2020·British Journal of Pharmacology·Erica BuosoMarco Racchi
Jul 10, 2019·Anti-cancer Agents in Medicinal Chemistry·Xuefeng LiuZhenyuan Wang
Oct 30, 2015·Oncotarget·Bàrbara CastellanaSantiago Ramón Y Cajal
May 5, 2017·Cancer Immunology Research·Christina EngelJasper G Van den Boorn

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