PMID: 40032Jul 31, 1979

On two-dimensional passive random walk in lipid bilayers and fluid pathways in biomembranes

The Journal of Membrane Biology
H J GallaE Sackmann

Abstract

The lateral mobility of pyrene, pyrene decanoic acid, and 1-palmitoyl-2-pyrene decanoyl-phosphatidyl choline (pyrene lecithin) in lipid bilayers is determined by the excimer formation technique. This method is applied to vesicles of lecithins differing in chain length and in the degree of saturation of the hydrocarbon chains. These values are compared with results in cephalins of different chain length and in dipalmitoyl phosphatidic acid at variable pH. The influence of cholesterol is investigated. The results are analyzed in terms of the Montroll model of two-dimensional random walk. The jump frequency of the probe molecule within the lipid lattice is obtained. The advantage of this measure of transport in lipid layers is that it does not involve lipid lattice parameters. The main results of the present work are: (i) The lateral mobility of a given solute molecule in lamellae of saturated lecithins is independent of hydrocarbon chain length and rather a universal function of temperature. (ii) In unsaturated dioleyl lecithin the amphiphatic molecules have lateral mobilities of the same size as in saturated lipids. The jump frequency of pyrene, however, is by a factor of two larger in the unsaturated lecithin. (iii) The jump fr...Continue Reading

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Related Concepts

Biological Membrane
Biochemical Pathway
Epicholesterol
Decanoic Acids
Tissue Membrane
Lecithinum, lecithin, Homeopathic preparation
Dipalmitoylphosphatidic acid
Pyrene
Decanoic acid
Vesicle

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