On variability and use of rat primary motor cortex responses in behavioral task discrimination

Journal of Neural Engineering
Winnie Jensen, P J Rousche

Abstract

The success of a cortical motor neuroprosthetic system will rely on the system's ability to effectively execute complex motor tasks in a changing environment. Invasive, intra-cortical electrodes have been successfully used to predict joint movement and grip force of a robotic arm/hand with a non-human primate (Chapin J K, Moxon K A, Markowitz R S and Nicolelis M A L 1999 Real-time control of a robotic arm using simultaneously recorded neurons in the motor cortex Nat. Neurosci. 2 664-70). It is well known that cortical encoding occurs with a high degree of cortical plasticity and depends on both the functional and behavioral context. Questions on the expected robustness of future motor prosthesis systems therefore still remain. The objective of the present work was to study the effect of minor changes in functional movement strategies on the M1 encoding. We compared the M1 encoding in freely moving, non-constrained animals that performed two similar behavioral tasks with the same end-goal, and investigated if these behavioral tasks could be discriminated based on the M1 recordings. The rats depressed a response paddle either with a set of restrictive bars ('WB') or without the bars ('WOB') placed in front of the paddle. The WB t...Continue Reading

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Citations

Feb 12, 2009·Medical & Biological Engineering & Computing·Michael Rizk, Patrick D Wolf
Jan 25, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·B Vikrham GowreesunkerRahul Gupta
Feb 20, 2010·Computational Intelligence and Neuroscience·Girish SinghalNitish Thakor
Mar 10, 2015·Journal of Neuroscience Methods·Kevin KahnSridevi V Sarma
Apr 27, 2016·IEEE Transactions on Bio-medical Engineering·Vijay Aditya TadipatriJames Ashe

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