Onabotulinumtoxin A for chronic migraine with medication overuse: clinical results of a long-term treatment

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
L Grazzi

Abstract

The use of Onabotulinumtoxin A as treatment for different neurological conditions is more common in the last decades; its application has been consolidated on the basis of significant clinical results. The clinical experiences with Onabotulinumtoxin A for chronic migraine are on the increase in Italy: at the moment, clinical results are encouraging and enforce the application of the toxin for chronic migraine, according to the results of the PREEMPT studies. The possibility for the patients to be treated with a second cycle of therapy after the first year of treatment is under discussion, in particular for patients who obtained significant clinical benefit from the first period of treatment. In this report, a group of patients treated with Onabotulinumtoxin A for 1 year, according to the PREEMPT protocol, has been retreated for one more year in order to confirm the clinical benefit obtained after the first year of treatment.

References

Dec 7, 2006·The Journal of Headache and Pain·Ivano FarinelliPaolo Martelletti
Jun 12, 2008·Annals of Neurology·Danièle RanouxD Bouhassira
Sep 4, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Licia GrazziGennaro Bussone
Jul 22, 2010·Cephalalgia : an International Journal of Headache·S K AuroraUNKNOWN PREEMPT 1 Chronic Migraine Study Group
Jul 22, 2010·Cephalalgia : an International Journal of Headache·H C DienerUNKNOWN PREEMPT 2 Chronic Migraine Study Group
Nov 11, 2010·Current Pain and Headache Reports·Aubrey N ManackRichard B Lipton
Nov 29, 2014·Cephalalgia : an International Journal of Headache·Eva Cernuda-MorollónJulio Pascual
May 29, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·L Grazzi, S Usai

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Citations

Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico
May 21, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H C DienerJ A Petersen
Dec 28, 2017·Expert Review of Neurotherapeutics·Cristina TassorelliPaolo Martelletti

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