OnabotulinumtoxinA and Hyaluronic Acid in Facial Wrinkles and Folds: A Prospective, Open-Label Comparison

Aesthetic Surgery Journal
Joel L CohenDee Anna Glaser

Abstract

OnabotulinumtoxinA and hyaluronic acid are effective in improving moderate to severe facial wrinkles and folds, with treatment selection traditionally based upon facial area. This prospective, multicenter, open-label, crossover study evaluated physician-rated efficacy and patient-rated outcomes following moderate to severe facial wrinkles and folds treatment with onabotulinumtoxinA and hyaluronic acid. 152 subjects (25-65 years) were randomized (1:1) to a treatment-sequence of onabotulinumtoxinA/hyaluronic acid or hyaluronic acid/onabotulinumtoxinA, with initial treatment administered on day 1 and 6 additional visits: week 2 (touch-up); week 4 (crossover); week 6 (touch-up); and weeks 8, 12, and 24 (follow-up). Between 92% and 100% of subjects in each treatment-sequence group exhibited at least some improvement from baseline at each study visit in the Physician Aesthetic Improvement Scale and the Objective Observer and Patient Global Assessments of Improvement, with no significant between-sequence differences. Subjects reported looking 3 to 6 years younger at each visit, with significant improvements in glabellar, lateral canthal, and horizontal forehead lines, and nasolabial folds. Treatments were well tolerated. Onabotulinumt...Continue Reading

References

May 1, 1996·Journal of the American Academy of Dermatology·A CarruthersJ Carruthers
Dec 3, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A Carruthers, J Carruthers
Nov 6, 2004·Aesthetic Plastic Surgery·Maurício de Maio
Jun 21, 2006·Dermatologic Therapy·Kiersten R Coleman, Jean Carruthers
Aug 16, 2006·Facial Plastic Surgery Clinics of North America·Corey S Maas
Jan 24, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jean Carruthers, Alastair Carruthers
May 28, 2008·Plastic and Reconstructive Surgery·Jean D A CarruthersUNKNOWN Facial Aesthetics Consensus Group Faculty
Jan 30, 2013·Aesthetic Plastic Surgery·Neil S SadickNils Krueger
Oct 8, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Derek Jones, Diane K Murphy
Oct 28, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alastair CarruthersFrederick Beddingfield
Dec 31, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Steven DayanElisabeth Lee
Apr 2, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Vic NarurkarConor Gallagher
May 15, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alastair CarruthersLinda Romagnano
Oct 28, 2015·Facial Plastic Surgery Clinics of North America·Ava Shamban
Mar 17, 2016·Aesthetic Surgery Journal·Alastair CarruthersConor J Gallagher
Apr 30, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Vic A NarurkarConor J Gallagher

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Citations

Mar 16, 2019·Aesthetic Surgery Journal·Achilleas ThomaJenny Santos

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