OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine

Pain
Eva Cernuda-MorollónJulio Pascual

Abstract

OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in patients with CM. Calcitonin gene-related peptide levels were determined in samples obtained from the right antecubital vein using ELISA, outside a migraine attack and having taken no symptomatic medication in the previous 24 hours, in 83 patients with CM (average age 44 years; 94% females) before and 1 month after treatment with 155 to 195 U of onabotA. CGRP levels after onabotA treatment (median, 51.89 pg/mL; range, 199.4-10.2) were significantly lower as compared with CGRP levels obtained before onabotA treatment (median, 74.09 pg/mL; range, 241.0-11.4; P = 0.001). Pretreatment CGRP levels in responders (76.85 pg/mL) were significantly higher than those seen in nonresponders (50.45 pg/mL; P = 0.001). One month after treatment, the CGRP levels did not change in nonresponders (51.89 pg/mL; P not significant), but significantly decreased in responders (52.48 pg/mL; P = 0.003). A number of demographic factors, clinical...Continue Reading

References

Jul 20, 2002·Current Rheumatology Reports·Thomas Graven-Nielsen, Lars Arendt-Nielsen
May 26, 2005·Brain Research. Brain Research Reviews·Lars Edvinsson, Rolf Uddman
Feb 16, 2007·Headache·Stephen D SilbersteinUNKNOWN Topiramate Chronic Migraine Study Group
Apr 20, 2007·Cephalalgia : an International Journal of Headache·H-C DienerUNKNOWN TOPMAT-MIG-201(TOP-CHROME) Study Group
Jun 23, 2009·Lancet Neurology·Jes OlesenPeer Tfelt-Hansen
Jul 21, 2009·Cephalalgia : an International Journal of Headache·J L NatoliR B Lipton
Aug 6, 2009·Handbook of Experimental Pharmacology·V S Seybold
May 11, 2010·The Journal of Headache and Pain·Henrik Winther SchytzMessoud Ashina
Jul 22, 2010·Cephalalgia : an International Journal of Headache·S K AuroraUNKNOWN PREEMPT 1 Chronic Migraine Study Group
Jul 22, 2010·Cephalalgia : an International Journal of Headache·H C DienerUNKNOWN PREEMPT 2 Chronic Migraine Study Group
Jul 20, 2011·Neurology·Eduardo E Benarroch
Sep 21, 2011·Nature Reviews. Neuroscience·Simon AkermanPeter J Goadsby
Nov 16, 2011·Headache·Paul L Durham, Roger Cady
Apr 20, 2013·Cephalalgia : an International Journal of Headache·Bernadett TukaJános Tajti
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Mar 13, 2014·Cephalalgia : an International Journal of Headache·Julio Pascual
Mar 26, 2014·BMJ : British Medical Journal·Todd J Schwedt
Apr 4, 2014·Cephalalgia : an International Journal of Headache·Rami BursteinMitchell F Brin

❮ Previous
Next ❯

Citations

Oct 24, 2015·British Journal of Pharmacology·Zdravko LackovićZsuzsanna Helyes
Oct 6, 2015·Medicina clínica·Nuria RiescoJulio Pascual
Jun 17, 2016·Expert Review of Neurotherapeutics·Andrea NegroPaolo Martelletti
Jul 9, 2016·Nature Reviews. Neurology·Arne May, Laura H Schulte
Sep 17, 2016·Headache·Eva Cernuda-MorollónJulio Pascual
Feb 2, 2017·Cephalalgia : an International Journal of Headache·Larus S GudmundssonJan Hoffmann
Feb 25, 2017·Current Opinion in Neurology·César RamónJulio Pascual
May 21, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Carlo Lovati, Luca Giani
Jan 25, 2017·Cephalalgia : an International Journal of Headache·Marta L RamosJulio Pascual
Nov 9, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Hsiangkuo YuanStephen D Silberstein
Oct 17, 2017·Der Internist·A Straube
Jun 16, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Carlo LovatiLeonardo Pantoni
Apr 15, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Reza FekrazadBahram Movahedi
Sep 22, 2018·Pain Management·Sameer JainStephen D Silberstein
Feb 20, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V NaprienkoL I Baiushkina
Jan 17, 2019·Clinical Pharmacology and Therapeutics·Hsiangkuo YuanStephen D Silberstein
Nov 7, 2017·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tommy L H ChanFarnaz Amoozegar
Apr 16, 2019·Headache·Smriti IyengarSheena K Aurora
May 6, 2019·Expert Review of Neurotherapeutics·János TajtiLászló Vécsei
Aug 3, 2019·The Journal of Dermatology·Philip CabreusAlma Rystedt
Nov 7, 2019·Current Pharmaceutical Design·Cinzia CavestroEugenia Rota
Jul 6, 2019·Cephalalgia : an International Journal of Headache·David García-AzorínÁngel L Guerrero
Mar 14, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Yi ZhangYuan Chen
Jan 19, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sonia QuintasÁngel L Guerrero
Mar 14, 2018·Drugs·James E Frampton, Stephen Silberstein
Apr 20, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Till SprengerC Tassorelli
Aug 8, 2019·Toxins·Ivica MatakZsuzsanna Helyes
Jul 11, 2019·Headache·Hsiangkuo YuanStephen D Silberstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.