PMID: 9692099Aug 6, 1998Paper

Once-daily budesonide in mild asthma

Respiratory Medicine
S L ChisholmH Petri

Abstract

Inhaled steroid therapy is the most important treatment in the management of chronic asthma and currently twice-daily administration is recommended in mild to moderate asthma. Compliance is often a problem in asymptomatic patients and may lead to reduced disease control. Our aim was to investigate whether budesonide 0.2 mg once daily administered via the Turbuhaler is as effective as 0.1 mg twice daily. A randomized, double-blind, parallel group study was carried out in which 76 adult patients with mild to moderate asthma (FEV1 86% of predicted) were allocated to budesonide once or twice daily. After a run-in period of 2 weeks on present inhaled steroid treatment (0.2-0.5 mg day-1) there was an 8 week treatment period, followed by a washout period in which patients received no steroid for 4 weeks unless a drop in morning peak flow of at least 20% occurred or the use of beta 2-agonists increased by 50%. Both treatment groups improved minimally in peak flow (1.7 and 4.31 min-1 in the once-daily and twice-daily groups respectively) but the differences between the two groups were not significant. Testing the reverse hypothesis revealed clinical equivalence. The 90% confidence interval of the difference in the change of peak flow fr...Continue Reading

References

Oct 1, 1990·Thorax·S LorentzsonG Persson
Oct 1, 1982·The Journal of Allergy and Clinical Immunology·J H ToogoodS A Johansson
Oct 1, 1994·The European Respiratory Journal·L ThorssonT B Conradson
Jul 1, 1993·Archives of Disease in Childhood·L Agertoft, S Pedersen
Apr 1, 1994·Respiratory Medicine·A H JonesP D Richardson
Jul 6, 1996·BMJ : British Medical Journal·B JonesA F Ebbutt
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

Citations

Apr 3, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·T B CasaleBengt Liljas
May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A S NayakJ E Harrison
Jan 30, 2004·Current Opinion in Pulmonary Medicine·Louis-Philippe Boulet
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·A Miller-LarssonR Brattsand
Dec 4, 2003·Clinical Therapeutics·R Brattsand, A Miller-Larsson
Dec 19, 2003·Journal of Clinical Pharmacology·Shashank RohatagiDonald Banerji
Jan 22, 2008·Respiratory Medicine·Edward M KerwinPaul M Dorinsky
Sep 2, 2004·Respiratory Medicine·Robert S ZeigerMIAMI Study Research Group
Dec 1, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jaro Ankerst
Mar 30, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Charles H Banov
Mar 9, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W J MetzgerMark Sugar
Jan 12, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·O SelroosChrister Hultquist
Nov 1, 2001·The Cochrane Database of Systematic Reviews·N AdamsP W Jones
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Matthew MasoliRichard Beasley

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.