PMID: 6989687Jan 1, 1980Paper

Once daily dose treatment with a non-steroidal anti-rheumatic drug (diclofenac) in osteoarthrosis

The Journal of International Medical Research
B I SchubigerK Tanner

Abstract

In a comparative, double-blind, between-patient, multicentre trial of 2 weeks' duration the efficacy and tolerability of diclofenac sodium 100 mg slow-release tablets, given either as a morning or an evening dose, were compared with that of diclofenac 50 mg enteric-coated tablets b.i.d. and placebo in 148 patients suffering from osteoarthrosis. Statistically significant differences in efficacy were shown between the two diclofenac slow-release regimes and placebo. Diclofenac 100 mg slow-release taken as a morning or an evening dose tended to be more effective than 50 mg enteric-coated tablets in a twice daily regime. The tolerability of diclofenac 100 mg slow-release and 50 mg enteric-coated b.i.d. regimes was similar and not statistically significantly different from placebo.

References

Jan 1, 1977·The Journal of International Medical Research·P Siraux
Jan 1, 1978·Scandinavian Journal of Rheumatology. Supplement·A Kajander, J Martio
Jan 1, 1978·Scandinavian Journal of Rheumatology. Supplement·A CarM Zivković
Jul 1, 1972·Clinical Pharmacology and Therapeutics·R B Stewart, L E Cluff
Jan 25, 1969·British Medical Journal·A M Porter
Dec 1, 1962·American Journal of Public Health and the Nation's Health·D SCHWARTZM E GOSS

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Citations

Dec 1, 1992·Alimentary Pharmacology & Therapeutics·G L SwiftF Khan
Nov 1, 1996·Journal of Microencapsulation·B AricaV Hasirci
Jan 1, 1993·Rheumatology International·M Schattenkirchner
Aug 1, 1996·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·E Superio-CabuslayK R Lorig

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