PMID: 8607560Oct 1, 1995Paper

Once daily fluticasone propionate aqueous nasal spray controls symptoms of most patients with seasonal allergic rhinitis

Allergy
B PedersenK N Nykanen

Abstract

This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not completely controlled with FPANS 200 micrograms od. A total of 549 patients initially received FPANS 200 micrograms od during the open-treatment phase of the study. After 2 weeks, 65% of patients had their symptoms well controlled by FPANS 200 micrograms od and continued with this treatment for a further 2 weeks. The remainder received either FPANS 200 micrograms od or FPANS 200 micrograms bd for a further 2 weeks. Efficacy was evaluated by the analysis of symptom-free days. In the uncontrolled group, there was a significant increase in the percentage of symptom-free days in the FPANS 200 micrograms bd group over the FPANS 200 micrograms od group for nasal blockage on waking (P < 0.05) and nasal blockage during the day (P < 0.05). Similar trends were observed for sneezing, rhinorrhoea, nasal itching, and eye symptoms. There was a significant increase in the percentage of days with a symptom score of less than 2 in FPANS...Continue Reading

Associated Clinical Trials

References

Nov 1, 1990·Respiratory Medicine·J BousquetF B Michel
Nov 1, 1990·Respiratory Medicine·S M Harding
May 1, 1988·The Journal of Allergy and Clinical Immunology·S C Siegel
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·A ReinbergC Ugolini
Dec 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R DarnellD H Richards

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Citations

Dec 21, 2000·Clinical Otolaryngology and Allied Sciences·G K ScaddingM J Price
Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology·Catherine Origlieri, Leonard Bielory
Feb 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D H Richards, C M Milton
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E KivisaariM J Price
Aug 23, 2006·Acta Oto-laryngologica·Niels Mygind, Morgan Andersson
Jan 27, 2007·The Cochrane Database of Systematic Reviews·J J Al SayyadA Jamal
Mar 15, 2002·Current Allergy and Asthma Reports·M Okuda, UNKNOWN US Food and Drug Administration (FDA)
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization

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