Once-daily i.v. BU-based conditioning regimen before allogeneic hematopoietic SCT: a study of influence of GST gene polymorphisms on BU pharmacokinetics and clinical outcomes in Chinese patients

Bone Marrow Transplantation
J YinY C Zhang

Abstract

I.v. BU has been proven to have better bioavailability, reliable systemic drug exposure with more predictable blood levels and lower toxicity than oral BU when used as part of conditioning regimens before hematopoietic SCT (HSCT). Some studies have shown that once-daily i.v. BU had the same clinical efficacy as i.v. BU administered four times daily. To observe the clinical efficacy and pharmacokinetics (PK) of once-daily i.v. BU and to evaluate the influence of glutathione S-transferase (GST) gene polymorphisms on once-daily i.v. BU PK in adult Chinese patients with allogeneic HSCT, we analyzed 25 patients receiving related or unrelated donor transplant conditioned with i.v. BU-based regimens. With a median follow-up of 32.7 months, the 2-year OS and EFS were 64 and 63.8% for all the patients, respectively, and the 2-year cumulative incidence of relapse for all patients was 18.3%. On the basis of HPLC analysis, the mean clearance and mean daily area under the curve (AUC) of i.v. BU were calculated as 4.02 mL/min per kg and 3380.77 μM/min, respectively. The estimated Cmax was 1.031±0.0325 μg/mL. The estimated t1/2 and Vd values were 3.618±0.1932 h and 1.212±0.0352 L/kg. The once-daily i.v. BU-based conditioning regimen was very ...Continue Reading

References

Nov 9, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·B S AnderssonW P Vaughan
Sep 6, 2001·Mutation Research·R C StrangeA A Fryer
Apr 10, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Borje S AnderssonRichard E Champlin
Apr 23, 2002·British Journal of Clinical Pharmacology·Serge CremersJaak Vossen
Oct 11, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J A RussellB S Andersson
Oct 11, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Borje S AnderssonRichard E Champlin
Oct 11, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hugo F FernandezMark S Goodman
Dec 20, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Borje S AnderssonRichard E Champlin
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·John D HayesIan R Jowsey
Feb 2, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Makiko KusamaTatsuji Iga
Jan 16, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Timothy MaddenBorje S Andersson
Aug 19, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Seong-Gil RyuKyoo-Hyung Lee
Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Imke H BartelinkJaap J Boelens
May 21, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Borje S AnderssonRichard E Champlin
Oct 16, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Borje S AnderssonRichard E Champlin
Dec 8, 2010·Journal of Clinical Pharmacology·Nissa AbbasiJeannine S McCune
Jan 11, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sung-Doo KimKyoo-Hyung Lee
Jul 9, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rosa F YehJeannine S McCune
Aug 2, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·S Bill KangarlooJames A Russell
Jan 8, 2013·Bone Marrow Transplantation·M AnsariUNKNOWN Pediatric Disease Working Parties of the European Blood and Marrow Transplant Group

❮ Previous
Next ❯

Citations

Apr 18, 2018·Journal of Clinical Pharmacology·Atsuko KawazoeSeongryul Kim
Feb 19, 2020·British Journal of Clinical Pharmacology·Jurgen B LangenhorstErik M van Maarseveen
May 31, 2017·International Journal of Clinical Pharmacy·Jing-Jing HuangWan-Hua Yang
Dec 3, 2021·Drug Metabolism and Personalized Therapy·Murilo Pita-Oliveira, Fernanda Rodrigues-Soares

❮ Previous
Next ❯

Related Concepts

Related Feeds

Buruli Ulcer

Buruli ulcer is a progressive disease of subcutaneous tissues caused by mycobacterium ulcerans. Here is the latest research.