Once daily ledipasvir/sofosbuvir fixed-dose combination with ribavirin in patients with inherited bleeding disorders and hepatitis C genotype 1 infection

Haemophilia : the Official Journal of the World Federation of Hemophilia
Catherine A M StedmanEdward Gane

Abstract

People with inherited bleeding disorders have been disproportionally affected by HCV. We assessed the fixed-dose combination of the NS5A inhibitor ledipasvir (LDV) with the NS5B polymerase inhibitor sofosbuvir (SOF) with ribavirin (RBV) in patients with genotype 1 HCV and inherited bleeding disorders. To be eligible, patients had to be over 18 years of age and have an inherited bleeding disorder. HCV treatment-naïve and -experienced patients could enrol. All patients received LDV 90 mg per SOF 400 mg once daily and weight-based RBV in a divided dose for 12 weeks. The primary efficacy endpoint was sustained virologic response (SVR), defined as HCV RNA below the limit of detection (15 IU mL-1 ) 12 weeks after the end of treatment (SVR12). Of the 14 patients enrolled, 8 (57%) had haemophilia A, 3 (21%) had haemophilia B and 2 (14%) had von Willebrand disease, and 1 (7%) had factor XIII deficiency. All 14 patients (100%, 95% CI: 77-100%) achieved SVR12. Treatment was well tolerated: all patients completed therapy, with mostly mild adverse events. No specific safety concerns associated with the patient's underlying bleeding disorders were noted. These results appear to suggest that people with HCV and inherited bleeding disorders ca...Continue Reading

References

Mar 22, 2008·The Journal of Antimicrobial Chemotherapy·Massimo FranchiniMario Cruciani
Jun 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·F Zoulim, F Bailly
Jan 4, 2013·The New England Journal of Medicine·Edward J GaneM Michelle Berrey
Aug 28, 2013·Journal of Hepatology·Dietje Elisabeth Fransen van de PutteEveline Pauline Mauser-Bunschoten
Apr 12, 2014·The New England Journal of Medicine·Kris V KowdleyUNKNOWN ION-3 Investigators
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-2 Investigators
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-1 Investigators

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Citations

Mar 5, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·K E ShermanA S Perelson
Jun 9, 2016·Hepatitis Monthly·Khashayar HesamizadehSeyed Moayed Alavian
Mar 19, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Ackens, D Posthouwer
Jun 17, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·James A D Freeman, Andrew Hill
Jul 14, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·M L WitkopB A Luxon
Oct 6, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·M HolmströmS Aleman
Mar 17, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·M Makris, B A Konkle
Jan 27, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·C E WalshK R Reddy
Mar 4, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe HézodeUNKNOWN C-EDGE IBLD Study Investigators
Feb 13, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·O GioulemeV Garipidou
May 23, 2019·Clinical Pharmacokinetics·Elise J SmoldersDavid M Burger
Dec 27, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Maria Elisa MancusoAlessio Aghemo
Jun 12, 2020·Seminars in Liver Disease·Manal H El-Sayed, Giuseppe Indolfi
May 4, 2017·Virology Journal·Mostafa H ElberryShaker A Mousa
Aug 5, 2018·Infectious Diseases and Therapy·Patricia A M KrachtKarel J van Erpecum
May 2, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ming-Lung YuWan-Long Chuang
May 7, 2021·British Journal of Haematology·Cas J IsfordinkMichael Makris
Apr 2, 2021·GE Portuguese Journal of Gastroenterology·Tiago Pereira GuedesIsabel Pedroto

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