Once-daily oxybutynin patch improves nocturia and sleep quality in Japanese patients with overactive bladder: Post-hoc analysis of a phase III randomized clinical trial

International Journal of Urology : Official Journal of the Japanese Urological Association
Osamu YokoyamaYu Masegi

Abstract

To investigate the efficacy of a once-daily oxybutynin patch for nocturia, and its influence on sleep quality in patients with overactive bladder. We carried out post-hoc analysis of a phase III, randomized, double-blind, comparative study in which an oxybutynin patch was administered once daily for 12 weeks to Japanese patients with overactive bladder. Patients with a baseline mean of one or more episodes of nocturia per night (data from voiding diaries) were analyzed. The mean number of micturitions, mean voided volume per micturition, mean first voided volume at night, mean sleep duration, and hours of undisturbed sleep were compared between the once-daily oxybutynin patch group and the placebo group. All parameters were expressed as the least squares mean values. The analysis included 576 patients. The number of nocturia episodes decreased by 0.66 in the oxybutynin patch group versus 0.51 in the placebo group (P = 0.0249). Also, the voided volume per nocturnal micturition and the first voided volume at night showed a significant increase in the oxybutynin patch group compared with the placebo group (P = 0.0073 and P = 0.0005, respectively). The hours of undisturbed sleep showed significant prolongation by 76.14 min in the o...Continue Reading

References

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Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
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Dec 20, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu YamaguchiUNKNOWN Oxybutynin Patch Study Group

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Citations

Jul 16, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Nobuhiro HagaYoshiyuki Kojima
Feb 2, 2020·Chest·Luigi Taranto-MontemurroScott A Sands
May 31, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshiro SuzukiOsamu Ishizuka

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