Once versus twice daily antihypertensive medications for the control of nocturnal blood pressure: a comparative study

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
Ghada YoussefAmr Abdel Aal

Abstract

Blood pressure (BP) shows short-term variability within the 24 h, which can only be assessed with 24-h ambulatory blood pressure monitoring (ABPM). It is of utmost importance to control BP throughout the night to reduce incidence of hypertension complications. The purpose of this study is to evaluate the effect of timing and frequency of antihypertensive medications on the average nighttime and 24-h blood pressure control. The study enrolled 199 hypertensive patients with controlled office blood pressure; 135 (67.8%) patients were on once daily antihypertensive medication (group 1) while 64 (32.2%) patients were on twice daily doses (group 2). The mean office SBP was 128.7 ± 7.8 mmHg in group 1 vs 129.6 ± 6.6 mmHg in group 2, (p = 0.421). ABPM readings for both groups were as follows: mean daytime SBP was 125.4 ± 11.6 mmHg vs 130.1 ± 12.9, p = 0.011; mean nighttime SBP was 117.0 ± 12.4 mmHg vs 123.1 ± 13.9 mmHg, p = 0.002, and mean 24-h SBP was 122.7 ± 10.6 mmHg vs 127.5 ± 12.0, p = 0.005. The prevalence of non-dipping was 68.9% in group 1 vs 70.3% in group 2 patients, p = 0.8 (the mean dipping ratio was 0.93 ± 0.08 in group 1 vs 0.95 ± 0.07 in group 2, p = 0.198). The prevalence of masked hypertension was higher in group 2 (28...Continue Reading

References

Mar 1, 2002·Journal of the American College of Cardiology·Paolo VerdecchiaGiuseppe Ambrosio
Jan 18, 2005·Lancet·Patricia M KearneyJiang He
Mar 6, 2009·The Annals of Pharmacotherapy·Richard A HansenMichael D Murray
Sep 22, 2010·Chronobiology International·Ramón C HermidaJosé R Fernández
Jan 14, 2012·Vascular Health and Risk Management·John M Flack, Samar A Nasser
Sep 14, 2013·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Dec 17, 2016·Diabetes Care
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Dec 29, 2018·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Ghada YoussefMagdy Abdel Hamid
Oct 24, 2019·European Heart Journal·Ramón C HermidaUNKNOWN Hygia Project Investigators

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