PMID: 15224803Jul 1, 2004Paper

Once-weekly epoetin alfa for treating the anemia of chronic kidney disease

Clinical Nephrology
Robert ProvenzanoPOWER Study Group

Abstract

Anemia occurs in approximately 47% of patients with chronic kidney disease (CKD) not on dialysis. Recombinant human erythropoietin (r-HuEPO, epoetin alfa) has been proven safe and effective for anemia treatment in patients with CKD using a three times-weekly regimen. The current study was conducted to evaluate the clinical safety and efficacy of a less frequent dosing regimen (once weekly) in this population. This prospective, multicenter, open-label, non-randomized study enrolled 1,557 adult anemic (hemoglobin (Hb) < or = 10 g/dl) CKD patients not on dialysis. Epoetin alfa 10,000 U was administered subcutaneously once weekly for 16 weeks. Titration to 20,000 U once weekly at week 5 was permitted if patients had an increase in Hb < 1 g/dl. Safety and efficacy were assessed by changes in health-related quality of life (Linear Analog Scale Assessment (LASA) and Kidney Disease Questionnaire (KDQ)), changes in hematologic parameters and transfusion utilization, and incidence and severity of adverse events. 1,338 patients were evaluable for efficacy. Mean Hb level increased from 9.1 g/dl at baseline to 11.6 g/dl at study completion (last observed value after baseline) (p < 0.0001). Overall, 89.8% of patients responded to once-weekly...Continue Reading

Citations

Mar 3, 2007·The New England Journal of Medicine·David S Riley
Jun 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael GermainMario Curzi
May 13, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Young Ki LeeJung Woo Noh
Feb 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karminder S GillBrian D Bradbury
Feb 7, 2008·Seminars in Dialysis·Ajay K Singh, Steven Fishbane
Nov 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Fredric O FinkelsteinSalim Mujais
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Pablo E PergolaPeter Bowers
Apr 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Tracy McGowanMarsha Wolfson
Apr 11, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Bruce SpinowitzUNKNOWN Epoetin Alfa Extended Dosing Study Group
Feb 27, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Pablo E PergolaPeter Bowers
Feb 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Moniek C M de GoeijUNKNOWN PREPARE-2 Study Group
Dec 16, 2011·Journal of Medical Economics·Marie-Hélène LafeuillePatrick Lefebvre
Jan 30, 2007·Current Medical Research and Opinion·Pierre-Yves CremieuxPatrick Lefebvre
May 20, 2006·Current Medical Research and Opinion·Frank J PapatheofanisCatherine Tak Piech
Oct 7, 2006·Current Medical Research and Opinion·Patrick LefebvrePierre-Yves Cremieux
Jan 13, 2016·Seminars in Dialysis·Donald Mitema, Bernard G Jaar
Dec 25, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shravanthi R GandraMona L Martin
Aug 5, 2008·The American Journal of Geriatric Pharmacotherapy·Marcia R SilverCatherine Stehman-Breen
Aug 21, 2007·Journal of Pain and Symptom Management·Dona E C LockeJan C Buckner
Mar 23, 2005·Critical Reviews in Oncology/hematology·Veerendra Munugalavadla, Reuben Kapur
Feb 2, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Miriam KimelJulia Dixon
Aug 18, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bradley A WaradyJeffrey Petersen
Jan 1, 2016·The American Journal of Hospice & Palliative Care·Hon Wai Benjamin ChengCarman Lam
Jul 13, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Thomas C Dowling
Sep 8, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Francis VekemanMei Sheng Duh
Nov 4, 2006·Journal of the American Society of Nephrology : JASN·Patrick LefebvreSamir H Mody
Sep 29, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charlotte Jones-BurtonJeffrey C Fink
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Robert BenzMarsha Wolfson
Jun 30, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Robert Provenzano, Ajay K Singh
Dec 9, 2020·Journal of the American Society of Nephrology : JASN·Robert TotoMatthew R Weir
Sep 28, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Daniel L LorberWilliam McClellan
Aug 9, 2005·Cardiology Clinics·Ravinder K Wali, William L Henrich
Apr 21, 2020·Kidney Diseases·Phillip StaibanoElianna Saidenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.