Abstract
Mass drug administration (MDA) of ivermectin has become the main intervention to control onchocerciasis or "river blindness". In Togo, after many years of MDA, Onchocerca volvulus infection has declined dramatically, and elimination appears achievable, but in certain river basins the current situation remains unknown. We have conducted parasitological, serological, ophthalmological, and entomological assessments in northern and central Togo within the river basins of Ôti, Kéran and Mô. Examinations were completed in 1,455 participants from 11 onchocerciasis sentinel villages, and O. volvulus transmission by Simulium damnosum sensu lato (s.l.) was evaluated. In children (aged 1-10 years), the prevalence of microfilariae (Mf) was 2.3% and in adults it ranged from 5.1 to 13.3%. Positive IgG4 responses to O. volvulus adult (crude) worm antigen (OvAg) and the recombinant Ov16 antigen were in all-ages 48.7% and 34.4%, and 29.1% and 14.9% in children, respectively. In the river basin villages of Kéran, Mô and Ôti, the IgG4 seroprevalences to OvAg in children were 51.7%, 23.5% and 12.7%, respectively, and to the Ov16 antigen 33.3% (Kéran) and 5.2% (Ôti). Onchocerciasis ocular lesions (punctate keratitis, evolving iridocyclitis and chor...Continue Reading
References
Jun 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R H BakerY Bissan
Jul 27, 1985·Lancet·M LariviereD Basset
Nov 1, 1995·The Journal of Infectious Diseases·C R KatholiT R Unnasch
Nov 24, 1998·Medical and Veterinary Entomology·D A BoakyeY Coulibaly
Jun 26, 2002·Annals of Tropical Medicine and Parasitology·M NomaA Sékétéli
Sep 28, 2006·PLoS Medicine·María-Gloria BasáñezMichel Boussinesq
Jan 18, 2007·Annals of Tropical Medicine and Parasitology·B Thylefors, M Alleman
Feb 17, 2007·Clinical and Experimental Immunology·C S MaiP T Soboslay
Sep 26, 2008·Annals of Tropical Medicine and Parasitology·B Boatin
Sep 26, 2008·Annals of Tropical Medicine and Parasitology·L Yaméogo
Jul 22, 2009·PLoS Neglected Tropical Diseases·Lamine DiawaraJan H F Remme
Aug 31, 2010·Acta Tropica·E W CuppF Richards
Dec 29, 2011·Microbes and Infection·Christian J LechnerPeter T Soboslay
Oct 3, 2012·PLoS Neglected Tropical Diseases·Mamadou O TraoreJan H F Remme
Feb 7, 2014·Parasites & Vectors·Jacinto ConvitMaría E Grillet
Jun 3, 2014·Parasites & Vectors·Hugo C TurnerMaría-Gloria Basáñez
Jun 3, 2014·PloS One·Méba BanlaPeter T Soboslay
Jun 20, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hugo C TurnerMaría-Gloria Basáñez
Apr 18, 2015·Parasites & Vectors·Samuel WanjiDavid W Taylor
Apr 22, 2015·PLoS Neglected Tropical Diseases·Poppy H L LambertonMaría-Gloria Basañez
Jun 13, 2015·Lancet·Darin S EvansFrank O Richards
Jul 15, 2015·PLoS Neglected Tropical Diseases·Mario A Rodríguez-PérezThomas R Unnasch
Oct 23, 2015·Parasites & Vectors·Wilma A StolkSake J de Vlas
Oct 28, 2015·The American Journal of Tropical Medicine and Hygiene·James W Kazura
Jan 16, 2016·PLoS Neglected Tropical Diseases·Simon J O'HanlonMaría-Gloria Basáñez
Jun 15, 2016·Parasites & Vectors·Allison GoldenGonzalo J Domingo
Aug 17, 2016·PLoS Neglected Tropical Diseases·Laura SenyonjoElizabeth Elhassan
Aug 24, 2016·Globalization and Health·Kenneth GustavsenSimon Bush
Nov 16, 2016·Parasites & Vectors·Guy-Roger KamgaAnnie Robert
Dec 8, 2016·PLoS Neglected Tropical Diseases·Nana O WilsonChristine Dubray
Dec 31, 2016·Acta Tropica·T LakwoM Katabarwa
Jan 25, 2017·Expert Review of Anti-infective Therapy·Robert A Cheke
Mar 11, 2017·Epidemics·Martin WalkerMaría-Gloria Basáñez
Citations
Dec 19, 2018·Clinical and Experimental Immunology·B WangalaP T Soboslay
Jan 5, 2020·Journal of Medical Entomology·Linda C OforkaHenry Y Fadamiro
Jul 28, 2020·Expert Review of Anti-infective Therapy·Philip MiltonMaría-Gloria Basáñez
Jan 31, 2020·Frontiers in Genetics·Shannon M HedtkeWarwick N Grant
Aug 14, 2020·BMC Public Health·Gebremedhin GebrezgabiherAsrat Hailu
Jul 5, 2019·Infectious Diseases of Poverty·Gebremedhin GebrezgabiherAsrat Hailu
Oct 22, 2020·Pathogens·Alfred DusabimanaRobert Colebunders
Oct 13, 2021·PLoS Neglected Tropical Diseases·Joseph PryceLisa J Reimer