Onchocerciasis-Associated Epilepsy, an Additional Reason for Strengthening Onchocerciasis Elimination Programs

Trends in Parasitology
R ColebundersAn Hotterbeekx

Abstract

A high prevalence of epilepsy has been observed in onchocerciasis-endemic regions with high onchocerciasis transmission. Recent epidemiological studies suggest that Onchocerca volvulus infection is the trigger causing the seizures, which appear in previously healthy children between the ages of 3 and 18 years. Persons with onchocerciasis-associated epilepsy present with a wide spectrum of seizures, including atonic and myoclonic neck seizures; but also absences and most frequently generalized tonic-clonic seizures. Often individuals present with intellectual disabilities and psychiatric disorders and occasionally with 'Nakalanga' features such as severe stunting with delayed or absent external signs of sexual development. Onchocerciasis-associated epilepsy, because of its importance as a public health problem, is an additional reason for strengthening onchocerciasis elimination programs.

Citations

Jul 18, 2019·PLoS Neglected Tropical Diseases·Joseph Nelson Siewe FodjoRobert Colebunders
Jul 19, 2019·PLoS Neglected Tropical Diseases·Robert ColebundersMaria-Gloria Basáñez
Aug 24, 2019·Infectious Diseases of Poverty·Joseph Nelson Siewe FodjoRobert Colebunders
Sep 26, 2019·Journal of Neuropathology and Experimental Neurology·An HotterbeekxRobert Colebunders
Jan 25, 2020·Annual Review of Pathology·Tory P JohnsonAvindra Nath
Mar 7, 2020·International Health·Joseph Nelson Siewe FodjoRobert Colebunders
May 20, 2020·Nature Reviews. Neurology·Gagandeep SinghJosemir W Sander
Oct 19, 2019·The Pediatric Infectious Disease Journal·Dan BhwanaRobert Colebunders
Oct 4, 2019·Infectious Diseases of Poverty·Robert ColebundersAdrian Hopkins
May 28, 2019·Infectious Diseases of Poverty·Christoph KaiserRobert Colebunders
Feb 11, 2019·Infectious Diseases of Poverty·Joseph Nelson Siewe FodjoRobert Colebunders
Aug 9, 2019·Tropical Medicine & International Health : TM & IH·R ColebundersJ Y Carter
Dec 7, 2019·Global Mental Health·D Geelhand de MerxemR Colebunders
May 3, 2019·Current Neurology and Neuroscience Reports·Mary C SpiciarichJorge Vidaurre
Sep 27, 2018·Infectious Diseases of Poverty·Natalie V S Vinkeles MelchersWilma A Stolk
Jan 8, 2021·PLoS Neglected Tropical Diseases·Robert ColebundersJoseph Nelson Siewe Fodjo
Dec 11, 2019·Lancet·Joseph Nelson Siewe FodjoRobert Colebunders
Jan 26, 2021·Journal of the Neurological Sciences·Jaime LunaPierre-Marie Preux
Aug 29, 2020·Acta Tropica·Norbert W BrattigRolf Garms
May 18, 2021·Frontiers in Cellular and Infection Microbiology·An HotterbeekxSamir Kumar-Singh
Nov 21, 2018·Brain Research Bulletin·An HotterbeekxRichard Idro

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