PMID: 8951112Nov 1, 1996Paper

Oncofetal fibronectin: new insight into the physiology of implantation and labor

Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
P A Dunn, R F Feinberg

Abstract

Oncofetal fibronectin is a newly studied protein produced by the trophoblast and is present in plasma and cervicovaginal secretions of pregnant women as labor approaches or when they have certain complications of pregnancy. Alterations in levels of oncofetal fibronectin occur in preterm labor, postterm pregnancy, and pregnancy-induced hypertension. Determining the presence or absence of full-term and preterm labor often is difficult in the clinical setting, and decision-making sometimes is hindered by the lack of a specific biochemical marker for labor. Oncofetal fibronectin may become a clinical indicator or predictor of true labor, preterm labor, or some complications of pregnancy. Assay techniques that identify clinically meaningful levels of oncofetal fibronectin are being developed and investigated and soon may be available to screen and identify pregnant women at risk. Research findings suggest new paths for investigation that may lead to important interventions in health care directed at identifying and decreasing maternal and neonatal morbidity and mortality. This article reviews pertinent aspects of placentation and the rationale for using oncofetal fibronectin detection as a clinical marker for abnormal pregnancy states.

References

Jan 1, 1992·Journal of Perinatal Medicine·M NeumanM Goldberg
Jan 1, 1992·Gynecologic and Obstetric Investigation·T ShimizuW Gibb
Jan 1, 1992·Gynecologic and Obstetric Investigation·N Kanayama, T Terao
May 1, 1992·Endocrinology·S GullerM Sonenberg
Mar 5, 1992·The New England Journal of Medicine·R F Feinberg, H J Kliman
Sep 5, 1991·The New England Journal of Medicine·C J LockwoodT J Garite
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·P J Steer
Oct 1, 1984·British Journal of Obstetrics and Gynaecology·A R Fuchs, F Fuchs
Feb 1, 1995·American Journal of Obstetrics and Gynecology·M J KupfermincM L Socol
Jul 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·S GullerC J Lockwood
Sep 1, 1993·Clinical Obstetrics and Gynecology·F J MeaneyJ G Davis
Feb 1, 1993·American Journal of Obstetrics and Gynecology·J C MorrisonR W Martin

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Citations

Feb 13, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M M G LeeflangG ter Riet
Jul 14, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Digna R Velez EdwardsScott M Williams

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