Oncofoetal antigens of human trophoblast

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
W P FaulkM Ueda

Abstract

Rabbits immunized with human trophoblast cell membranes produced antibodies that were detected, by immunofluorescence, to react with normal human tissues, and, by complement-mediated cytotoxicity, with several transformed human cell lines. Absorption with trophoblast abolished all of these reactions, whereas multiple absorptions with lymphocytes, liver or kidney failed to remove reactivity with either trophoblast or certain transformed cells. To further identify the antigens responsible for these antibodies, rabbits were immunized with a chromatographed fraction of deoxycholate-solubilzed membranes prepared from KCl-extracted, ultracentrifuge-prepared trophoblast microvilli. The resultant IgG antibody reacted specifically with syncytiotrophoblastic membranes in sections of human placentae, in addition to recognizing the membranes of viable Chang liver, AV3, HEp-2, Sw/156 (kidney) and Sw/527 (breast) cells. That normal tissues, baboon or monkey placentae, and HeLa or Daudi cell lines did not react with this antibody, indicates the presence of species- and organ-specific antigens in human trophoblast, as well as the existence of trophoblast cross-reactive antigens on some transformed cells. The selective localization of these ant...Continue Reading

References

Apr 13, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M E Bramwell, H Harris

Citations

Nov 1, 1981·Journal of Reproductive Immunology·M J O'SullivanW P Faulk
Jun 1, 1985·Journal of Reproductive Immunology·M Davies, C M Browne
Nov 1, 1987·Journal of Reproductive Immunology·B L HsiP L Stern
Dec 1, 1989·Journal of Reproductive Immunology·C S Bambra, M Isahakia
Feb 1, 1982·Human Immunology·J A McIntyre, W P Faulk
Jan 1, 1981·Journal of Immunological Methods·C D OcklefordW P Faulk
Jan 1, 1988·American Journal of Obstetrics and Gynecology·W P FaulkP J Stevens
Oct 1, 1989·British Journal of Haematology·G J AndersonJ W Halliday
Mar 1, 1984·American Journal of Reproductive Immunology : AJRI·D A ClarkJ Rossant
Jan 1, 1983·Immunological Reviews·W P Faulk, J A McIntyre
Jan 1, 1983·American Journal of Reproductive Immunology : AJRI·D EmersonR M Galbraith
Dec 1, 1984·American Journal of Reproductive Immunology : AJRI·M WellsW P Faulk
Sep 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·B L HsiC Grivaux
Mar 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·K TatsumiT Mori
Jul 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·J A McIntyre
Jan 1, 1981·American Journal of Reproductive Immunology : AJRI·P M JohnsonL C Shah
Dec 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·D DegenneP Bardos
Oct 1, 1984·American Journal of Reproductive Immunology : AJRI·S SinhaG P Talwar

Related Concepts

Metazoa
Carcinoembryonic Antigen
Plasma Membrane
Cross Reactions
Microcytotoxicity Test
Immunofluorescence Assay
Immune Sera
Immunosorbent Techniques
Chinchilla Rabbits
Syncytiotrophoblasts

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