Oncofoetal antigens of human trophoblast

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
W P FaulkM Ueda


Rabbits immunized with human trophoblast cell membranes produced antibodies that were detected, by immunofluorescence, to react with normal human tissues, and, by complement-mediated cytotoxicity, with several transformed human cell lines. Absorption with trophoblast abolished all of these reactions, whereas multiple absorptions with lymphocytes, liver or kidney failed to remove reactivity with either trophoblast or certain transformed cells. To further identify the antigens responsible for these antibodies, rabbits were immunized with a chromatographed fraction of deoxycholate-solubilzed membranes prepared from KCl-extracted, ultracentrifuge-prepared trophoblast microvilli. The resultant IgG antibody reacted specifically with syncytiotrophoblastic membranes in sections of human placentae, in addition to recognizing the membranes of viable Chang liver, AV3, HEp-2, Sw/156 (kidney) and Sw/527 (breast) cells. That normal tissues, baboon or monkey placentae, and HeLa or Daudi cell lines did not react with this antibody, indicates the presence of species- and organ-specific antigens in human trophoblast, as well as the existence of trophoblast cross-reactive antigens on some transformed cells. The selective localization of these ant...Continue Reading


Apr 13, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M E Bramwell, H Harris


Nov 1, 1981·Journal of Reproductive Immunology·M J O'SullivanW P Faulk
Jun 1, 1985·Journal of Reproductive Immunology·M Davies, C M Browne
Nov 1, 1987·Journal of Reproductive Immunology·B L HsiP L Stern
Dec 1, 1989·Journal of Reproductive Immunology·C S Bambra, M Isahakia
Feb 1, 1982·Human Immunology·J A McIntyre, W P Faulk
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Jan 1, 1988·American Journal of Obstetrics and Gynecology·W P FaulkP J Stevens
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Mar 1, 1984·American Journal of Reproductive Immunology : AJRI·D A ClarkJ Rossant
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Dec 1, 1984·American Journal of Reproductive Immunology : AJRI·M WellsW P Faulk
Sep 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·B L HsiC Grivaux
Mar 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·K TatsumiT Mori
Jul 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·J A McIntyre
Jan 1, 1981·American Journal of Reproductive Immunology : AJRI·P M JohnsonL C Shah
Dec 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·D DegenneP Bardos
Oct 1, 1984·American Journal of Reproductive Immunology : AJRI·S SinhaG P Talwar

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