Oncogene c-Myc promotes epitranscriptome m6 A reader YTHDF1 expression in colorectal cancer

Oncotarget
Yujiro NishizawaHideshi Ishii

Abstract

Recent studies that have emerged on the diversity of RNA modification in tumors suggest their eligibility as bona fide targets in diagnosis and drug discovery. N6-methyladenosine (m6A) was first reported and is most common in epitranscriptome modification of various RNAs. The YT521-B homology (YTH) domain family are representative m6A-binding proteins, but how the YTH domain family is involved in cancer remains to be clearly understood. Given that clinical sequence data in colorectal cancer indicate that overexpression of YTHDF1 is outstanding among other family members, we studied the role of Ythdf1 and the transcriptional control of YTHDF1. Immunostaining of Ythdf1 showed that its expression was associated with various malignant tumor behaviors, such as depth, lymph node metastasis, and poorer cancer stages. The study of patient survival indicated that patients with high Ythdf1 expression had significantly poorer overall survival. The results indicated that Ythdf1 expression is an independent prognostic factor of patients. The in vitro study showed that the knockdown of YTHDF1 resulted in the suppression of cancer proliferation and sensitization to the exposure of anticancer drugs such as fluorouracil and oxaliplatin. Importa...Continue Reading

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Citations

Sep 12, 2019·International Journal of Cancer. Journal International Du Cancer·Jianbo TianXiaoping Miao
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Methods Mentioned

BETA
immunoprecipitation
transfection
PCR
electrophoresis

Software Mentioned

JMP Pro

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