Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

The Journal of Cell Biology
Tomohiro MizutaniHans Clevers

Abstract

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jun 14, 2005·Cancer Cell·Yardena SamuelsVictor E Velculescu
Apr 25, 2012·Cancer Research·Alyssa A LeystraRichard B Halberg
Aug 2, 2013·Science Translational Medicine·Ryan B CorcoranJeffrey A Engelman
Apr 30, 2015·Nature·Jarno DrostHans Clevers
Jun 18, 2016·Cell·Hans Clevers
Dec 29, 2016·EMBO Molecular Medicine·Kelly KerstenJos Jonkers
Mar 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Arianna FumagalliJacco van Rheenen
Apr 27, 2017·The Journal of Cell Biology·Pamela RiemerMarkus Morkel

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