DOI: 10.1101/493627Dec 13, 2018Paper

Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently

BioRxiv : the Preprint Server for Biology
Andrei MakashovA P Kozlov


Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggested to call them TSEEN genes, i.e. Tumor Specifically Expressed, Evolutionarily New genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm predictions made by our hypothesis of the possible evolutionary role of hereditary tumors.

Related Concepts

Cell Differentiation Process
Biological Evolution
Neoplastic Syndromes, Hereditary
Tumor Suppressor Genes
Human gene
Protein Expression

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