PMID: 8995627Feb 1, 1997Paper

Oncogenesis of mammary glands, skin, and bones by polyomavirus correlates with viral persistence and prolonged genome replication potential

Journal of Virology
J J WirthM M Fluck

Abstract

A correlation between polyomavirus-induced oncogenesis and viral persistence on the one hand and/or prolonged genome replication potential on the other was established with respect to their respective organ distributions. Prolonged replication potential is defined as the capacity of a genome to replicate in a given organ from the time of infection up to the onset of oncogenesis. This conclusion was derived following intraperitoneal infection of BALB/c mice with wild-type strain A2. Viral genomes were used as parameters of persistence and replication and were detected by Southern blotting and PCR analysis. The major tumor target organs (mammary gland, skin, and bone), which have not been previously analyzed for persistence, were compared with other, non-tumor-prone organs (kidney, liver, lung, spleen, and salivary gland). A progressive loss of viral genomes was observed in all tissues as a function of time postinfection; however, genomes were shown to persist through 20 weeks postinfection in the mammary glands, skin, and bones to an extent similar to that in the previously described kidneys (D. J. McCance, J. Virol. 39:958-962, 1981; W. P. Rowe, J. W. Hartley, J. D. Estes, and R. J. Huebner, Natl. Cancer Inst. Monogr. 4:189-209...Continue Reading

References

Jun 1, 1992·Journal of Virology·J J WirthM M Fluck
Jun 1, 1992·Journal of Virology·R RochfordL P Villarreal
Jan 1, 1991·Journal of Virology·T W DubenskyT L Benjamin
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J ZulloR L Garcea
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·B E GriffinA Cowie
Apr 1, 1959·The Journal of Experimental Medicine·W P ROWER J HUEBNER

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