Oncogenic β-catenin mutations evade pH-regulated degradation

Molecular & Cellular Oncology
Bree K Grillo-Hill, Katharine A White

Abstract

β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilitates β-TrCP binding and degradation of β-catenin. β-catenin mutations that abrogate the pH-sensitive interaction induce significant tumors not seen with other β-catenin stabilizing mutants.

References

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Oct 14, 2018·The Journal of Cell Biology·Katharine A WhiteDiane L Barber

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Methods Mentioned

BETA
ubiquitination

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