Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1

Oncogene
M OsanaiG-H Lee

Abstract

Vitamin A deficiency (VAD) is associated with increased susceptibility to carcinogenesis in animal models and elevated risk for a number of human cancers. Here, we found that CYP26A1, the gene encoding a cytochrome P450 enzyme specifically involved in metabolic inactivation of retinoic acid (RA), the most active vitamin A derivative, is highly expressed in 42% (27/65) of primary breast cancers. We also showed that enhanced expression of CYP26A1 suppresses cellular responses to anoikis and consequently promotes anchorage-independent growth. This transformed phenotype was sufficient to markedly increase tumorigenic and metastatic potential. Suppression of CYP26A1 significantly reversed the CYP26A1-mediated oncogenic characteristics, suggesting a direct link between intracellular RA status and tumorigenicity. Our observations provide strong evidence for oncogenic and cell survival properties of CYP26A1 in carcinogenesis, and suggest mechanisms whereby VAD might promote cancer development.

References

Jul 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Lotan
May 1, 1997·Leukemia & Lymphoma·M KizakiY Ikeda
Oct 9, 1997·The New England Journal of Medicine·P Fenaux, L Degos
May 18, 2001·Nature·G I Evan, K H Vousden
Oct 19, 2001·Journal of the American Academy of Dermatology·P M Petkovich
Mar 21, 2002·Nature Reviews. Cancer·L Altucci, H Gronemeyer
Jun 4, 2002·Nature Cell Biology·Or GozaniJunying Yuan
Feb 11, 2005·Molecular Pharmacology·Makoto Osanai, Martin Petkovich
Nov 30, 1925·The Journal of Experimental Medicine·S B Wolbach, P R Howe

❮ Previous
Next ❯

Citations

Dec 17, 2010·Genes & Development·Benjamin L Martin, David Kimelman
Nov 16, 2010·Annual Review of Pathology·Xiao-Han Tang, Lorraine J Gudas
May 3, 2011·Annual Review of Nutrition·A Catharine Ross, Reza Zolfaghari
Dec 20, 2011·Medical Molecular Morphology·Makoto Osanai, Gang-Hong Lee
Jan 29, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yanling ChenMenghang Xia
Mar 13, 2016·Seminars in Oncology·Iván P UrayPowel H Brown
Aug 19, 2014·International Journal of Cancer. Journal International Du Cancer·Julien Ablain, Hugues de Thé
Jul 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Irina FavorskayaElena Tchevkina
May 27, 2015·Medical Molecular Morphology·Makoto Osanai, Gang-Hong Lee
Oct 3, 2018·Critical Reviews in Food Science and Nutrition·Xiaoling NiXun Cai
Feb 6, 2020·Journal of Clinical Medicine·Lara CostantiniNicolò Merendino
Dec 7, 2019·Cancers·Orsola di Martino, John S Welch
Dec 7, 2018·Frontiers in Genetics·Yaroslav R EfremovSergey S Bogachev
Oct 10, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anatoliy I YashinSvetlana V Ukraintseva
Nov 26, 2020·Diagnostics·Ping-Ho ChenLeong-Perng Chan
Jan 31, 2021·Molecular and Cellular Biochemistry·Zhenzhen JiangYuhui Hua
Nov 4, 2021·Journal of Food Biochemistry·Hasan TurkezAdil Mardinoglu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.