Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome

PloS One
Claudia GrosseAlexandra Grosse

Abstract

Lung cancer in never smokers is recognized as a distinct molecular, clinicopathologic and epidemiologic entity. The aim of the study was to investigate the molecular profile in Swiss never smokers with lung adenocarcinoma and to correlate the mutation status with clinicopathologic and demographic patient characteristics and outcome. One hundred thirty-eight never smokers diagnosed with lung adenocarcinoma at the University Hospital Zurich between 2011-2018 were included in the study. Data from the electronic medical records were reviewed to characterize clinicopathologic and demographic features, molecular profile, treatment and outcome. The majority of patients were female (58.7%) with a median age at diagnosis of 64.5 years (range, 27.1-94.2 years). The most common mutations were EGFR (58.7%) followed by ALK (12.3%), TP53 (5.8%), MET (5.8%), KRAS (4.3%), ERBB2 (4.3%), PIK3CA (2.9%), BRAF (2.2%), ROS1 (1.4%), RET (1.4%), CTNNB1 (0.7%), PARP1 (0.7%), TET1 (0.7%) and PIK3CG (0.7%). Median overall survival (mOS) was 51.0 months (mo). Early clinical stage (p = 0.002) and treatment with targeted therapy (HR 2.53, 95% CI 1.35-4.74, p = 0.004) were independently associated with longer mOS. Patients with oncogenic driver mutations had...Continue Reading

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Citations

May 19, 2020·American Society of Clinical Oncology Educational Book·Antonio CallesJulie R Brahmer
Sep 16, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rony F ArauzBríd M Ryan
May 15, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Véronique HofmanPaul Hofman

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Methods Mentioned

BETA
biopsy
biopsies
genotyping
PCR
surgical resection

Software Mentioned

SPSS

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