PMID: 19923885Nov 20, 2009Paper

Oncogenic ILK, tumor suppression and all that JNK

Cell Cycle
Adam David DurbinDavid Malkin

Abstract

In neoplastic cells, proteins exert either pro or anti-tumorigenic functions. However, some proteins exhibit both properties, commonly dependent on specific aberrations occurring in a tumor-specific context. Recently, we demonstrated that the integrin-linked kinase (ILK), generally characterized as an oncogenic protein kinase, functions as a tumor suppressor protein in vitro and in vivo in the aggressive pediatric tumor, rhabdomyosarcoma (RMS). Other studies have similarly demonstrated both growth and tumor suppressive functions for ILK in normal and transformed tissues. The mechanism of ILK tumor suppression in RMS relies on expression levels of another kinase, the c-jun amino terminal kinase-1 (JNK1). These findings support a model in which ILK tumor suppression is mediated in part by elevated JNK1 expression, and indicate both a rationale for stratification of patients to receive anti-ILK therapies, and a need to better understand the context in which ILK displays its seemingly contradictory functions. This review discusses the complex roles of ILK in tumorigenesis, and offers arguments to harness ILK and JNK signaling as novel targets for anti-cancer therapy.

Citations

Oct 16, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinghe LiSenlin Chen
Nov 26, 2010·Nature Reviews. Cancer·Sara CabodiPaola Defilippi
Aug 28, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F PoschS B Watzka
Sep 24, 2015·Scientific Reports·William S TobelaimCaroline Saucier
Aug 13, 2013·Gene·A A StepanenkoV M Kavsan
Feb 15, 2012·Cellular Signalling·Hua ZhangGeorgios Giamas
Mar 22, 2014·Nature Reviews. Molecular Cell Biology·Sabina E Winograd-KatzKyle R Legate
Jul 5, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Noor A HusseinAmit K Tiwari

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