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Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment

Cancer Discovery

Feb 13, 2020

Prasenjit DeyRonald A DePinho

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Abstract

A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. Here, we explored the role of oncogenic Kras in pro-tumorigenic signaling interactions between cancer cells and host cells. We show tha...read more

Mentioned in this Paper

T-helper Cell Type 2
IL13RA1 protein, human
Gene Expression Profiling
Cell Type
KRAS gene
STAT6 protein, human
Protein Expression
Stroma
Cytokine
IL4
57
Paper Details
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Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment

Cancer Discovery

Feb 13, 2020

Prasenjit DeyRonald A DePinho

PMID: 32046984

DOI: 10.1158/2159-8290.cd-19-0297

Abstract

A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. Here, we explored the role of oncogenic Kras in pro-tumorigenic signaling interactions between cancer cells and host cells. We show tha...read more

Mentioned in this Paper

T-helper Cell Type 2
IL13RA1 protein, human
Gene Expression Profiling
Cell Type
KRAS gene
STAT6 protein, human
Protein Expression
Stroma
Cytokine
IL4
57

Feeds With Similar Papers

Gene Regulation, Differentiation & Reprogramming (Keystone)

This feed focuses on alterations of gene regulation during cell differentation and reprogramming processes. Here is the latest research on gene regulation in differentiation and reprogramming processes.

Metabolomics

Metabolomics refers to the large-scale study of profiling all metabolites in biological systems in a non-targeted manner. Here is the latest research.

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Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors

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Paper Details
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