Sep 16, 2014

Differences in post-mating transcriptional responses between conspecific and heterospecific matings in Drosophila

bioRxiv
LAURA ORELLANAMODESTO OROZCO

Abstract

In many animal species, females undergo physiological and behavioral changes after mating. Some of these changes are driven by male-derived seminal fluid proteins, and are critical for fertilization success. Unfortunately, our understanding of the molecular interplay between female and male reproductive proteins remains superficial. Here we analyze the post-mating response in a Drosophila species that has evolved strong gametic incompatibility with its sister species; D. novamexicana females produce only ~1% fertilized eggs in crosses with D. americana males, compared to ~98% produced in within-species crosses. This incompatibility is likely caused by mismatched male and female reproductive molecules. In this study we use short-read RNA sequencing to examine the evolutionary dynamics of female reproductive genes and the post-mating transcriptome response in crosses within and between species. First, we found that most female reproductive tract genes are slow-evolving compared to the genome average. Second, post-mating responses in con- and heterospecific matings are largely congruent, but heterospecific mating induces expression of additional stress-response genes. Some of those are immunity genes that are activated by the Imd ...Continue Reading

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Mentioned in this Paper

EGFR
CFC1 gene
Extracellular
Epidermal Growth Factor Receptor Activity
Molecular_function
Macromolecular Alteration
Gene Deletion Abnormality
Gene Deletion
Deletion Mutation
Epidermal Growth Factor Receptor

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