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Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation

bioRxiv

Sep 16, 2014

Laura OrellanaModesto Orozco

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Abstract

Epidermal Growth Factor Receptor (EGFR) signalling is supposed to be triggered by a ligand-induced conformational change of the extracellular domain from a closed, self-inhibited tethered monomer, to an open untethered state with a free dimerization arm. The ectodomain also untethers sp...read more

Mentioned in this Paper

Extracellular Domain
Mutant
Ligands
Doxorubicin hydrochloride liposome
Simulation
Point Mutation
Epidermal growth factor receptor VIII
Extracellular
Research Study
Macromolecular Alteration
2
9
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  • Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation

    bioRxiv

    Sep 16, 2014

    Laura OrellanaModesto Orozco

    PMID: 990009068

    DOI: 10.1101/009068

    Abstract

    Epidermal Growth Factor Receptor (EGFR) signalling is supposed to be triggered by a ligand-induced conformational change of the extracellular domain from a closed, self-inhibited tethered monomer, to an open untethered state with a free dimerization arm. The ectodomain also untethers sp...read more

    Mentioned in this Paper

    Extracellular Domain
    Mutant
    Ligands
    Doxorubicin hydrochloride liposome
    Simulation
    2
    9

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