Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor. Case report

Journal of Neurosurgery
K DavidH A Crockard

Abstract

A 60-year-old woman suffered from hypophosphatemic osteomalacia secondary to a frontal intracranial tumor. Oral administration of phosphate and 1-alpha-hydroxyvitamin D3 provided only temporary symptomatic relief. A computerized tomography (CT) scan of the patient's head revealed a large subfrontal tumor attached to the dura. Following removal of the tumor, the patient's hypophosphatemia subsided; her level of 1,25-dihydroxyvitamin D3, which was undetectable preoperatively, returned to normal, and she had symptomatic improvement. Three years later, decreasing levels of phosphate and 1,25-dihydroxyvitamin D3 indicated tumor recurrence, before it was detected by CT scan. Histological examination of the tumor provided the diagnosis of "mixed connective tissue variant of phosphaturic mesenchymal tumor." The characteristic histological features of this relatively rare entity are discussed. This is the first report of a surgically treated intracranial phosphaturic mesenchymal tumor that caused oncogenic osteomalacia.

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Citations

May 3, 2011·Skeletal Radiology·Pallavi SuryawanshiNirmala Ajit Jambhekar
Feb 9, 2010·Acta Neuropathologica·Wojciech BiernatKrzysztof Sworczak
May 25, 2011·Southern Medical Journal·Waseem KhaliqKrishnarao Tangella
Jul 4, 2012·Journal of Medical Case Reports·Isao ChokyuKenji Ohata
Mar 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Erik A Imel, Michael J Econs
May 16, 2009·Journal of Neurosurgery. Spine·Elena PirolaErik Pietro Sganzerla
Jan 29, 2013·Journal of Neurosurgery·Derek A MathisJack Raisanen
Sep 1, 2011·Nuclear Medicine and Molecular Imaging·Hyo Jung SeoWon Jun Kang
Jan 2, 2016·Journal of Neurosurgery. Pediatrics·Mark B EllisIman Feiz-Erfan
Jul 2, 2019·Advances in Anatomic Pathology·Michele BiscegliaAlfredo Scillitani
Oct 7, 2018·Medicine·Xian XiaoTing Xie
Apr 28, 2004·The Journal of Craniofacial Surgery·Claudio UngariMario Pagnoni
May 21, 2010·International Journal of Oral and Maxillofacial Surgery·M PedrazzoliL Autelitano

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