Oncogenic Properties of the EBV ZEBRA Protein

Cancers
Diego GerminiYegor Vassetzky

Abstract

Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary infection, it can persist in the host throughout their lifetime in a latent form, from which it can reactivate following specific stimuli. EBV reactivation is triggered by transcriptional transactivator proteins ZEBRA (also known as Z, EB-1, Zta or BZLF1) and RTA (also known as BRLF1). Here we discuss the structural and functional features of ZEBRA, its role in oncogenesis and its possible implication as a prognostic or diagnostic marker. Modulation of host gene expression by ZEBRA can deregulate the immune surveillance, allow the immune escape, and favor tumor progression. It also interacts with host proteins, thereby modifying their functions. ZEBRA is released into the bloodstream by infected cells and can potentially penetrate any cell through its cell-penetrating domain; therefore, it can also change the fate of non-infected cells. The features of ZEBRA described in this review outline its importance in EBV-related malignancies.

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Citations

Jan 30, 2021·Frontiers in Microbiology·Juliette SavoretNathalie Chazal
Mar 7, 2021·Viruses·Marco QuagliaVincenzo Cantaluppi
May 31, 2021·Tumour Virus Research·Lori Frappier

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Methods Mentioned

BETA
electrophoresis
immunoprecipitation
biopsies
enzyme-linked immunosorbent assay
xenograft

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