Oncologic emergencies: Pathophysiology, presentation, diagnosis, and treatment

CA: a Cancer Journal for Clinicians
Mark A LewisTimothy J Moynihan


Oncologic emergencies can occur at any time during the course of a malignancy, from the presenting symptom to end-stage disease. Although some of these conditions are related to cancer therapy, they are by no means confined to the period of initial diagnosis and active treatment. In the setting of recurrent malignancy, these events can occur years after the surveillance of a cancer patient has been appropriately transferred from a medical oncologist to a primary care provider. As such, awareness of a patient's cancer history and its possible complications forms an important part of any clinician's knowledge base. Prompt identification of and intervention in these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. This article reviews hypercalcemia, hyponatremia, hypoglycemia, tumor lysis syndrome, cardiac tamponade, superior vena cava syndrome, neutropenic fever, spinal cord compression, increased intracranial pressure, seizures, hyperviscosity syndrome, leukostasis, and airway obstruction in patients with malignancies. Chemotherapeutic emergencies are also addressed.


Jun 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J H LadensonJ C Boyd
Sep 1, 1977·Archives of Internal Medicine·F M GrundP Burns
May 6, 1978·British Medical Journal·A L Harris
Sep 6, 1979·The New England Journal of Medicine·L H Beck
May 1, 1977·Neurology·Y UshioW R Shapiro
Jan 1, 1978·Annals of Neurology·R W GilbertJ B Posner
Aug 1, 1978·Circulation·P S ReddyJ A Shaver
Aug 1, 1978·Journal of Clinical Pathology·A M Jackson, D I Graham
Apr 21, 1977·The New England Journal of Medicine·S J GinsbergA V Fitzpatrick
May 1, 1992·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·P L KwittkenS Sweinberg
Aug 12, 1992·JAMA : the Journal of the American Medical Association·R A DeyoD L Kent
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M P MehtaT J Kinsella
Nov 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·J J van der SandeW Boogerd
Jan 1, 1990·The Annals of Thoracic Surgery·T F ChenF C Wells
Oct 1, 1989·The Annals of Thoracic Surgery·D J Mathisen, H C Grillo
Mar 15, 1989·Annals of Internal Medicine·M AllonC Copkney
Sep 1, 1988·The Journal of Emergency Medicine·G Sternbach
Jun 1, 1988·Clinical Cardiology·A ColomboJ M Gardin
Aug 1, 1972·The American Journal of the Medical Sciences·J Buxbaum
Nov 1, 1965·The Journal of Clinical Investigation·R ShabetaiM Masangkay
Aug 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R Ahmann
Nov 1, 1982·Bulletin of the New York Academy of Medicine·S C Schimpff
Jun 1, 1981·The American Journal of Medicine·D E SchraufnagelJ A Pare
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·E Maranzano, P Latini
Apr 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·G Bertelli
Feb 1, 1995·American Journal of Clinical Oncology·N T Sklarin, M Markham
Jan 1, 1993·Journal of Clinical Apheresis·B C McLeodH G Klein
Mar 1, 1994·Southern Medical Journal·I A MalikA Khan
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S SørensenH H Hansen

❮ Previous
Next ❯


Aug 25, 2011·World Journal of Surgical Oncology·Kassem HarrisMichel Chalhoub
Jun 13, 2015·Cancer Investigation·Jason D WrightDawn L Hershman
Dec 24, 2013·Advances in Chronic Kidney Disease·F Perry Wilson, Jeffrey S Berns
Aug 21, 2015·International Journal of Clinical Practice·J MiellC Jamookeeah
Jan 26, 2016·Expert Opinion on Drug Safety·Gary H LymanEva Culakova
Aug 4, 2015·Respiratory Medicine Case Reports·Azriel Avezbadalov, Cristina Gutierrez
May 27, 2014·Journal of Critical Care·Eirini KostakouAntonia Koutsoukou
Aug 15, 2014·World Neurosurgery·Emilie Chan-SengNicolas Lonjon
Jun 17, 2014·Cancer Treatment Reviews·M R F BosscherH J Hoekstra
Apr 19, 2016·International Journal of Cancer. Journal International Du Cancer·Harry ComberJonathan Pratschke
Jun 28, 2016·CA: a Cancer Journal for Clinicians·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Aug 27, 2014·BMJ Case Reports·Ronald Jan TrofBert Beishuizen
Jan 8, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Minsoo KimKyung Soo Lim
Oct 16, 2013·Circulation·Aaron D GoldbergRobert F Padera
Mar 9, 2012·Clinical and Molecular Allergy : CMA·Hana SalehGuha Krishnaswamy
Jan 23, 2020·Cancer·L Nicolas Gonzalez Castro, Tracey A Milligan
Aug 11, 2012·Clinical Journal of the American Society of Nephrology : CJASN·F Perry Wilson, Jeffrey S Berns
Sep 26, 2017·Clinical Journal of Oncology Nursing·Beth Faiman
Sep 26, 2017·Clinical Journal of Oncology Nursing·Kevin BrigleTeresa Miceli
Feb 9, 2021·Acute Medicine & Surgery·Tomoaki TorigoeKazuo Saita
Jan 29, 2021·Medicina·Agnieszka StyczeńTomasz Zapolski

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Care Clinics
Deepti BehlTimothy J Moynihan
Journal of Palliative Medicine
Fareeha Siddiqui, David E Weissman
Medizinische Klinik, Intensivmedizin und Notfallmedizin
M von Bergwelt-BaildonM Kochanek
© 2022 Meta ULC. All rights reserved