Abstract
To report contemporary treatment outcomes of penile squamous cell carcinoma at a UK supraregional center, including patterns of therapy, oncologic results, and long-term survival. Patients with squamous cell carcinoma treated during the period January 2000 to January 2011 were included. Records were reviewed to identify the mode of therapy (penile preserving or amputative surgery), pathology reports (reclassified according to the 2009 tumor-nodes-metastasis classification), recurrence patterns, and cancer-specific survival (CSS). Kaplan-Meier plots were used for survival analyses. Two hundred three patients were identified with a median follow-up of 61 months. At presentation, 165 patients (82%) were node negative, 31 (15%) were node positive, and 7 (3%) had metastatic disease. Management was penile preserving surgery (n = 99, 49%), partial penectomy (n = 49, 24%), radical penectomy (n = 48, 24%), and chemotherapy or radiotherapy for metastatic disease (n = 7, 3%). After organ-preserving surgery, the local recurrence rate was 18% (compared with 4% for amputative surgery), with 94% of recurrences occurring within 3 years. Histopathologic staging was as follows, with pTis (20%), pT1 (27%), pT2 (27%), pT3 (7%), and pT4 (1%). Kapla...Continue Reading
References
May 15, 1982·Cancer·A S NarayanaD A Culp
Nov 1, 1993·British Journal of Urology·R Ravi
Feb 15, 2000·BJU International·A AgrawalC Ratnakar
Jun 7, 2002·The Journal of Urology·P J TanisS Horenblas
Mar 12, 2003·The Journal of Urology·Ulrico Jacobellis
May 6, 2004·The Journal of Urology·B K KroonO E Nieweg
Dec 22, 2004·BJU International·Alastair W S RitchieUNKNOWN BAUS Section of Oncology
Oct 18, 2005·BJU International·Suks MinhasDavid Ralph
Jan 21, 2006·Journal of Surgical Oncology·Durgatosh PandeyR Ravi Kannan
Feb 14, 2007·The Journal of Urology·Anne P LontSimon Horenblas
Feb 24, 2007·European Urology·Joost A P LeijteSimon Horenblas
Jul 19, 2008·World Journal of Urology·Paul K HegartyDavid J Ralph
Aug 5, 2008·European Urology·Vincenzo Ficarra, Giacomo Novara
Jun 16, 2009·The Journal of Urology·Gustavo Cardoso GuimarãesAntonio L Cubilla
Oct 20, 2009·The Journal of Urology·Robert S SvatekCurtis A Pettaway
Feb 19, 2010·European Urology·Giorgio PizzocaroUNKNOWN European Association of Urology (EAU) Guidelines Group on Penile Cancer
Apr 18, 2012·Annals of the Royal College of Surgeons of England·P KumarD J Summerton
Aug 7, 2013·The Journal of Urology·Rosa S DjajadiningratSimon Horenblas
Oct 9, 2013·Cancer Causes & Control : CCC·Manit AryaMichel P Coleman
Citations
Mar 15, 2015·Urology·Curtis A Pettaway
Dec 29, 2016·The Journal of Urology·Fardod O'KellyPaul Hegarty
May 8, 2019·World Journal of Urology·Andrea Katharina LindnerRenate Pichler
Jan 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Satheesh KrishnaRonaldo Hueb Baroni
Aug 6, 2020·Journal of Palliative Care·Facundo M DavaroZachary A Hamilton
Jan 25, 2017·The Journal of Urology·Jonathan S O'BrienNathan Lawrentschuk
Jul 1, 2017·Current Oncology Reports·Tanya B DorffAnne K Schuckman
Aug 20, 2020·Nature Reviews. Urology·Ahmet Murat AydinPhilippe E Spiess
May 10, 2019·F1000Research·Maximilian J Johnston, Raj Nigam
Aug 1, 2020·Scandinavian Journal of Urology·Sophia Liff MaibomPeter Meidahl Petersen
Jan 27, 2019·Annals of Surgical Oncology·Curtis A Pettaway
Oct 9, 2020·Acta Oncologica·Emma UlvskogJohan Ahlgren
Oct 27, 2020·Journal of Cancer Research and Clinical Oncology·Andrey SoaresJosé de Ribamar Rodrigues Calixto
Nov 13, 2020·BJU International·Eduard RousselUNKNOWN eUROGEN, the Young Academic Urologists (YAU) Working Group of Men’s Health
Jan 17, 2021·Der Urologe. Ausg. A·A ThomasI Tsaur
May 27, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·S AndersonP Sweeney
Jul 27, 2021·Urology·Julián ChavarriagaRodolfo Varela
Aug 10, 2021·Emergency Medicine International·Demis N LipeMonica K Wattana
Jul 6, 2021·Urologic Oncology·Timothy A Masterson, Scott T Tagawa