Oncological Characteristics of Radiological Invasive Adenocarcinoma with Additional Ground-Glass Nodules on Initial Thin-Section Computed Tomography: Comparison with Solitary Invasive Adenocarcinoma

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Aritoshi HattoriKenji Suzuki

Abstract

We aimed to evaluate the oncological outcomes of radiological invasive adenocarcinoma with additional ground-glass nodules (AGGNs) on initial thin-section computed tomography (CT). We examined 473 patients with surgically resected clinical stage IA lung adenocarcinoma showing a radiological invasive appearance on thin-section CT. Radiological invasiveness was defined as a solid tumor with a consolidation tumor ratio of at least 0.5 but no greater than 1.0 on thin-section CT. Ninety patients (19%) had dominant invasive adenocarcinoma (DA) with AGGNs, whereas 383 (81%) had solitary invasive adenocarcinoma (SA). DA showed a significantly lower maximum standardized uptake value of (18)F-fluorodeoxyglucose on positron emission tomography (p = 0.0086), higher frequency of radiological part solid tumor (p = 0.0232) and histological lepidic predominant tumor (p = 0.0015), and lesser presence of nodal involvement (p = 0.0350) and lymphovascular invasion (p = 0.0001) than with SA. Surgically resected AGGNs were shown to be pathologically atypical adenomatous hyperplasia in 17% of patients, adenocarcinoma in situ in 53%, and minimally invasive adenocarcinoma in 21%. Furthermore, the 5-year overall survival of DA with AGGNs was better than...Continue Reading

References

Jul 4, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ramón Rami-PortaUNKNOWN Participating Institutions
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
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Oct 28, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Madeline VazquezUNKNOWN International Early Lung Cancer Action Program Investigators
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Feb 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kenji SuzukiUNKNOWN Japan Lung Cancer Surgical Study Group (JCOG LCSSG)
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
May 9, 2012·The Annals of Thoracic Surgery·Aritoshi HattoriShiaki Oh
Jun 29, 2013·The Annals of Thoracic Surgery·Bo GuJoseph B Shrager
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Jan 30, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kyuichi KadotaWilliam D Travis

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Citations

Mar 5, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aritoshi HattoriKenji Suzuki
Apr 19, 2017·Japanese Journal of Clinical Oncology·Aritoshi HattoriKenji Suzuki
Oct 3, 2018·Japanese Journal of Clinical Oncology·Aritoshi HattoriKenji Suzuki
Oct 9, 2019·The Annals of Thoracic Surgery·Aritoshi HattoriKenji Suzuki
Jul 28, 2020·The Journal of Thoracic and Cardiovascular Surgery·Fangqiu FuHaiquan Chen
Jul 28, 2020·The Journal of Thoracic and Cardiovascular Surgery·Nobuyuki YoshiyasuToru Bando

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