Oncological outcome after radical cystectomy and orthotopic bladder substitution in women

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Bedeir Ali-El-Dein

Abstract

The pathological outcome after radical cystectomy and orthotopic bladder substitution in women and the possibility of genital sparing are studied in a prospective way. Between January 1995 and June 2003, 180 women with bladder cancer (mean age 50.6 years) underwent orthotopic neobladder reconstruction. Histopathologic assessment of the cystectomy specimens was performed. Involvement of the internal genitalia by primary or secondary cancer was evaluated by preoperative CT or MRI. Histopathological evaluation of these organs was made in the cystectomy specimens. Mean follow-up was 57 months. At follow-up, isolated urethral recurrence developed in two patients. Local pelvic recurrence developed in 30 patients, distant metastasis in 14 and both in nine. Uterine infiltration, which was suspected by preoperative CT, was confirmed by definitive histopathology after radical cystectomy in only two cases; otherwise there were no primary or secondary malignancies of the internal genitalia. Isolated recurrence of bladder cancer in the vaginal remnant during follow-up after cystectomy was not noted in any woman. The rate of urethral recurrence and oncological failure after orthotopic bladder substitution in women is low and acceptable and t...Continue Reading

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Citations

Jul 14, 2010·Future Oncology·Mohamed Saad Zaghloul
Jul 12, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H Salem, A El-Mazny
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Nov 1, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji Sung ShimSeok Ho Kang
Nov 27, 2019·Urology·Hrishikesh Das, Ronald Rodriguez
May 8, 2021·Hematology/oncology Clinics of North America·Vivek Venkatramani, Dipen Jaysukhlal Parekh
Jul 17, 2021·Urologic Oncology·Ekaterina LaukhtinaUNKNOWN European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

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