Oncological outcomes of repeat metastasectomy for recurrence after hepatectomy for colorectal liver metastases. A case series

Annals of Medicine and Surgery
Yoshiaki MaedaTomonori Hamada

Abstract

Although hepatectomy is the standard and only curative treatment for colorectal liver metastases, recurrence occurs in various organs, including the remnant liver, lung, peritoneum, and others. The outcomes and predictive factors of repeat metastasectomy for recurrence after initial hepatectomy remains controversial. We retrospectively assessed a consecutive series of 132 patients who underwent hepatectomy for colorectal liver metastases in a single institute. There were 99 recurrence cases after initial hepatectomy, and 42 patients underwent metastasectomy (first repeat metastasectomy) to achieve R0 (17 liver cases, 16 lung cases, and 9 multiple or other cases), while 19 patients underwent subsequent second repeat metastasectomy (4 liver cases, 7 lung cases, and 8 multiple or other cases). Among the 99 recurrent cases after initial hepatectomy, the 5-year overall survival rate of the patients who underwent first repeat metastasectomy was significantly higher than that of chemotherapy/BSC (best supportive care) patients (60% vs. 14%, P < 0.0001). Furthermore, among the 26 recurrent cases after first repeat metastasectomy, the 5-year overall survival rate of the patients who underwent second repeat metastasectomy was significant...Continue Reading

References

Jan 1, 1997·Annals of Surgery·R AdamL Engerran
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
May 8, 2003·The British Journal of Surgery·D EliasP Lasser
Apr 9, 2005·Surgery Today·Gen SugawaraAkihiro Yamaguchi
Jul 22, 2006·Annals of Surgery·Sylvain ManfrediAnne-Marie Bouvier
Dec 19, 2007·Archives of Surgery·Antonio Sa CunhaJean Saric
Nov 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Sharad SharmaNicolas Jabbour
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Oct 2, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mechteld C de JongTimothy M Pawlik
Aug 23, 2011·Clinical Colorectal Cancer·Renata FerrarottoScott Kopetz
Jul 23, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Oliver ZiffJ Peter A Lodge
Jun 26, 2014·Annals of Surgical Oncology·Akio SaiuraNorihiro Kokudo
Feb 27, 2015·World Journal of Gastroenterology : WJG·Huisong LeeHo-Kyung Chun
Jan 27, 2016·World Journal of Gastroenterology : WJG·Giovanni BrandiGuido Biasco
Mar 24, 2016·International Journal of Cancer. Journal International Du Cancer·Hiroki OsumiToshiharu Yamaguchi
Jul 31, 2016·World Journal of Surgical Oncology·Seok KimHee Cheol Kim
Oct 5, 2016·American Journal of Surgery·Sulaiman NanjiChristopher M Booth
Dec 1, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Aurélien DupréGraeme J Poston
Jan 1, 2016·Cancer Treatment and Research·Vikrom DharSyed A Ahmad
Oct 26, 2018·International Journal of Surgery·Riaz A AghaUNKNOWN PROCESS Group
May 24, 2019·Cancer Management and Research·Valentinus T ValdimarssonChristian Sturesson
Jun 15, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shin KobayashiKenichi Sugihara
Jul 13, 2019·Annals of Surgical Treatment and Research·Jangho ParkJungnam Joo

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

EZR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.