Oncological outcomes, quality of life outcomes and complications of partial cystectomy for selected cases of muscle-invasive bladder cancer

Scientific Reports
Jan EbbingCarsten Kempkensteffen

Abstract

To evaluate the oncological results, associated complications, and postoperative health-related quality of life (HR-QoL) in patients treated with partial cystectomy (PC) for muscle-invasive bladder cancer (MIBC). 27 patients who underwent open PC for cT2 MIBC were included. A simple Cox's proportional hazards regression model was used to assess the association of several potential prognostic factors with survival. Postoperative HR-QoL was assessed with the EORTC (European Organisation for the Research and Treatment of Cancer) QLQ-C30 questionnaire version 3.0. Final pathological tumour stages in PC specimen were: pT0: 18.5%, non-MIBC: 3.7%, MIBC: 74.1%, pCIS: 14.8%. Estimated 5-year overall- and progression-free survival rates were 53.7% and 62.1%. Five (18.5%) patients experienced local recurrence with MIBC. Overall, the salvage cystectomy rate was 18.5%. The 90-day mortality rate was 0%. Significant risk factors for progression-free survival were vascular invasion (HR 5.33) and tumour multilocularity (HR 4.5) in the PC specimen, and a ureteric reimplantation during PC (HR 4.53). The rates of intraoperative complications, 30- and 90-day major complications were 7.4%, respectively and 14.8% for overall long-term complications. ...Continue Reading

References

Oct 1, 1979·The Journal of Urology·T W SchoborgC W Lewis
Feb 1, 1978·The Journal of Urology·W BrannanG R Landry
Nov 1, 1976·The Journal of Urology·A C Novick, B H Stewart
Jun 1, 1973·The Journal of Urology·M I Resnick, V J O'Conor
Jan 1, 1984·Scandinavian Journal of Urology and Nephrology·F LindahlK Egvad
Sep 1, 1995·Journal of Surgical Oncology·N P DandekarM R Kamat
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P SteinD G Skinner
Oct 4, 2002·European Urology·Haluk KulaksizogluErdinç Unlüer
Aug 12, 2005·The Journal of Urology·Brent K HollenbeckJohn T Wei
Jan 18, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Matthias MayMichael Siegsmund
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Oct 6, 2009·Urology·Harry W Herr
Sep 2, 2014·Health and Quality of Life Outcomes·Salvatore SiracusanoEmanuele Belgrano
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jan 13, 2015·Current Opinion in Urology·John Knoedler, Igor Frank
May 22, 2016·BJU International·David M GolombosDouglas S Scherr
Jul 5, 2016·European Urology·J Alfred WitjesMaria J Ribal
Jan 1, 2014·International Scholarly Research Notices·Wassim M BazziHarry W Herr
Nov 16, 2016·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Nitesh PatidarAnil Mandhani
Dec 30, 2016·Current Opinion in Urology·Thomas R W HerrmannMario W Kramer

❮ Previous
Next ❯

Citations

Jan 22, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Judy HamadAngela Smith
Mar 5, 2020·Expert Review of Anticancer Therapy·Gregory J NasonGirish S Kulkarni
Nov 3, 2021·Current Opinion in Supportive and Palliative Care·Taylor GoodsteinCheryl T Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Expert Review of Pharmacoeconomics & Outcomes Research
Gemma CramarossaEdward Chow
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Gemma CramarossaAndrew Bottomley
Annals of Oncology : Official Journal of the European Society for Medical Oncology
D E EdiebahQuality of Life Department and Patient Reported Outcome and Behavioural Evidence (PROBE)
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
K CocksJ M Brown
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Tanja LangsenlehnerKarin S Kapp
© 2022 Meta ULC. All rights reserved