PMID: 25756136Mar 11, 2015Paper

Oncological predictive value of the 2004 World Health Organisation grading classification in primary T1 non-muscle-invasive bladder cancer. A step forward or back?

BJU International
Federico PellucchiRenzo Colombo

Abstract

To compare the clinical reliability of the 1973 and 2004 World Health Organisation (WHO) classification systems in pT1 bladder cancer. We retrospectively evaluated 291 consecutive patients who had pT1 high grade bladder cancer between 2004 and 2011. All tumours were simultaneously evaluated by a single uro-pathologist as high grade and G2 or G3. All patients underwent a second transurethral resection (TUR) and those confirmed with non-muscle-invasive bladder cancer at second TUR received bacille Calmette-Guérin. Follow-up included urine cytology and cystoscopy 3 months after second TUR and then every 6 months for 5 years. Univariate and multivariate analysis to determine recurrence-free survival (RFS) and progression-free survival (PFS) rates were performed using the Kaplan–Meier method with the log-rank test. G2 tumours were found in 124 (46.6%) and G3 in 142 (53.4%) patients. The mean (median; range) follow-up period was 31.1 (19; 1–93) months. The 5-year RFS rate was 39.1% for the overall high grade population, and 49.1 and 31.8% for G2 and G3 subgroups, respectively. The 5-year PFS was 82% for the overall high grade population and 89 and 73% for G2 and G3 subgroups, respectively. RFS (P < 0.002) and PFS (P < 0.001) rates we...Continue Reading

References

Feb 27, 2007·Journal of Clinical Pathology·Lorna CottrellMario Hair
Nov 13, 2007·The Journal of Urology·M Craig HallPaul F Schellhammer
Apr 13, 2011·Virchows Archiv : an International Journal of Pathology·Burçin TunaZiya Kirkali
Nov 1, 2011·European Urology·Bas W G van RhijnAlexandre R Zlotta
Jan 21, 2012·The American Journal of Surgical Pathology·Wei-Chin ChangChin-Chen Pan
May 1, 2012·Human Pathology·Liang ChengAntonio Lopez-Beltran
Jun 16, 2012·European Urology·Fredrik LiedbergUNKNOWN Lund Bladder Cancer Group
Apr 16, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Peter E ClarkUNKNOWN National Comprehensive Cancer Network (NCCN)
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology

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Citations

Jul 1, 2015·Current Opinion in Urology·Elisabeth E Fransen van de PutteBas W G van Rhijn
Dec 20, 2018·Histopathology·Martin J MagersLiang Cheng
Jan 12, 2021·European Urology Oncology·Bas W G van RhijnUNKNOWN Multi-center EAU Non-Muscle-Invasive Bladder Cancer Guidelines Panel Study Consortium on the WHO1973 WHO 2004 2016 Classific

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