Oncologist volume and outcomes in older adults diagnosed with diffuse large B cell lymphoma

Cancer
Scott F HuntingtonAmy J Davidoff

Abstract

Although provider-level volume is frequently associated with outcomes in cancers requiring complex surgeries, whether similar relations exist for cancers treated primarily with systemic therapy is unknown. Using a population-based cohort analysis of older adults diagnosed with diffuse large B cell lymphoma (DLBCL) during the years 2004-2011, we evaluated the association between oncologist volume and 4 clinical outcomes (receipt of any chemotherapy, receipt of an anthracycline-containing or equivalent regimen, early hospitalization, and overall survival). Our primary explanatory variable was lymphoma treatment volume, defined as the number of patients with newly diagnosed lymphoma for which an oncologist initiated therapy during a 12-month look-back period from each incident DLBCL case. We identified 8247 Medicare beneficiaries who were newly diagnosed with DLBCL. Chemotherapy was administered to 6202 (75.2%) beneficiaries, and 71.4% of cytotoxic regimens contained an anthracycline. Beneficiaries who were treated by higher-volume oncologists had increased odds of receiving chemotherapy (adjusted odds ratio [aOR], 1.45; 95% confidence interval [CI], 1.24-1.70; P <.001) and of receiving an anthracycline-containing regimen (aOR, 1....Continue Reading

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Citations

Dec 14, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Julie HalletNatalie G Coburn
Jun 14, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Sina J TorabiBenjamin L Judson
Mar 7, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Julie HalletNatalie Coburn
Jun 25, 2021·Urologic Oncology·Kelly R PekalaBruce L Jacobs

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