Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity

Cancers
Praveensingh B HajeriMasato Yamamoto

Abstract

Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.

References

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Citations

Oct 1, 2020·International Journal of Molecular Sciences·Masakazu Hamada, Yoshiaki Yura
Oct 30, 2020·Cancers·Mizuho Sato-DahlmanMasato Yamamoto
Mar 7, 2021·Cancers·Aleksei TitovEmil Bulatov
Nov 26, 2021·Frontiers in Chemistry·Panyong ZhuBo Yang

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Methods Mentioned

BETA
surgical resection
phage display
peptide display
targeted modifications

Software Mentioned

pIX

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