Oncolytic and immunologic cancer therapy with GM-CSF-armed vaccinia virus of Tian Tan strain Guang9

Cancer Letters
Lili DengBiao Huang

Abstract

Targeted oncolytic vaccinia viruses are being developed as a novel strategy in cancer therapy. Arming vaccinia viruses with immunostimulatory cytokines can enhance antitumor efficacy. Such engineered oncolytic viruses, like JX-594, a Wyeth strain vaccinia virus modified with human granulocyte-macrophage colony-stimulating factor (GM-CSF), have shown promising results and have proceeded rapidly in clinical trials. However, the oncolytic potential of the Chinese vaccine strain Tian Tan (VTT) has not been explored. In this study, we constructed a targeted oncolytic vaccinia virus of Tian Tan strain Guang9 (VG9) expressing murine GM-CSF (VG9-GMCSF) and evaluated the antitumor effect of this recombinant vaccinia virus in a murine melanoma model. In vitro, viral replication and cytotoxicity of VG9-GMCSF was as potent as VG9; in vivo, VG9-GMCSF significantly inhibited the growth of subcutaneously implanted melanoma tumors, prolonged the survival of tumor-bearing mice, and produced an antitumor cytotoxic response. Such antitumor effect may be due to the lytic nature of virus as well as the stimulation of immune activity by GM-CSF production. Our results indicate that VG9-GMCSF induces strong tumoricidal activity, providing a potential ...Continue Reading

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Citations

Mar 29, 2019·Expert Opinion on Biological Therapy·Lino E Torres-Domínguez, Grant McFadden
Jun 2, 2017·The Open Virology Journal·Tiantian ZhangKarim Essani
Nov 12, 2019·Cell Biochemistry and Function·Zhihao ZhangZujiang Yu
Oct 8, 2018·Journal of Cancer Research and Clinical Oncology·Xue YangZhigang Hu
Jan 11, 2019·Journal for Immunotherapy of Cancer·Zong Sheng GuoDavid L Bartlett
May 26, 2017·Biomedicines·Nicholas L DentonTimothy P Cripe
Dec 5, 2020·Journal of Clinical Laboratory Analysis·Chunming WangYigang Wang
Feb 20, 2021·Human Vaccines & Immunotherapeutics·Ziling ZhangJianqing Xu

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