PMID: 11905600Mar 22, 2002Paper

Oncolytic biotherapy: a novel therapeutic plafform

The Lancet Oncology
Lynda K HawkinsDavid Kirn

Abstract

There is a clear need for new, selective, cancer treatments that do not cause the cross-resistance which occurs with currently available chemotherapeutic agents. Gene therapy is a promising approach, but to date, it has shown limited effectiveness in clinical trials because of insufficient gene transduction. Many investigators are now revisiting the 'old' idea of using tumour-specific, replication-selective viruses or bacteria to treat cancer. These agents can be directly oncolytic, but can also be used to simultaneously express therapeutic genes in target cells or induce tumour-specific, cell-mediated immunity. We discuss the promise of this rapidly evolving field and examine the potential barriers to its success.

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
Jul 5, 1991·Science·M HollsteinC C Harris
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·M GromeierE Wimmer
Jun 14, 1996·The Journal of Biological Chemistry·K S CannonA Helenius
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·B Roizman
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·B Moss
Dec 6, 1996·Science·C J Sherr
Nov 13, 1998·Science·M C CoffeyP W Lee
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J N ParkerJ M Markert
Apr 5, 2000·The Journal of Clinical Investigation·R L Martuza
Apr 5, 2000·The Journal of Clinical Investigation·C Heise, D H Kirn
Apr 20, 2000·The Journal of Clinical Investigation·M SznolI King
Apr 20, 2000·The Journal of Clinical Investigation·M J MastrangeloE C Lattime
Apr 20, 2000·The Journal of Clinical Investigation·K L Norman, P W Lee
May 3, 2000·The Journal of Clinical Investigation·S Agha-Mohammadi, M T Lotze
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·M GromeierE Wimmer

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Citations

Aug 7, 2003·Trends in Biotechnology·Wout A M WolkenMariët J van der Werf
Feb 4, 2005·Gene Therapy·B H Shen, T W Hermiston
May 17, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Josh A NoserYasuhiro Ikeda
Jan 6, 2009·Uirusu·Toshiyoshi Fujiwara, Noriaki Tanaka
Jan 1, 2010·Ecancermedicalscience·P KanavosZ Vlachopioti
Oct 15, 2003·Clinical Lymphoma·Tommy AlainAnna E Kossakowska
Mar 15, 2008·International Journal of Cancer. Journal International Du Cancer·Masayoshi HiokiToshiyoshi Fujiwara
Aug 6, 2010·Expert Opinion on Biological Therapy·Dong-Sheng PeiJun-Nian Zheng
Jan 17, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yasumoto YamasakiToshiyoshi Fujiwara
Feb 17, 2009·Expert Opinion on Biological Therapy·Toshiyoshi Fujiwara
Jul 2, 2016·Cancers·Alexandra M MowdayAdam V Patterson
Jan 15, 2011·Cancer Treatment Reviews·M G BourkeG C O'Sullivan
Sep 24, 2016·Journal for Immunotherapy of Cancer·Hasan RehmanHoward L Kaufman
Apr 21, 2011·Expert Review of Anticancer Therapy·Toshiyoshi FujiwaraShunsuke Kagawa
Jun 15, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ta-Chiang LiuDavid Kirn
May 3, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Heidrun EnglerSusan E Conroy
Jul 21, 2005·Technology in Cancer Research & Treatment·T RobsonD G Hirst
Feb 9, 2018·Human Vaccines & Immunotherapeutics·Robert M ConryTimothy Graham Norwood
Apr 19, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Mee Rie Sheen, Steven Fiering
Nov 20, 2004·Cancer Gene Therapy·Marta Izquierdo
Mar 25, 2016·Journal of Virology·Xing ChengHong Jin
Apr 14, 2005·European Journal of Gastroenterology & Hepatology·Bruno SangroJesus Prieto

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