Oncolytic herpes viral therapy is effective in the treatment of hepatocellular carcinoma cell lines.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Tae-Jin SongYuman Fong

Abstract

The rising incidence of hepatocellular carcinoma (HCC) in western countries, along with the poor prognosis offered by present-day treatment modalities, makes novel therapies for this disease necessary. Oncolytic herpes simplex viruses (HSV) are replication-competent viruses that are highly effective in the treatment of a wide variety of experimental models of human malignancies. This study seeks to investigate the effectiveness of oncolytic herpes viruses in the treatment of primary HCC cell lines. Sixteen commercially available human HCC cell lines were studied. G207 is an attenuated, replication-competent, oncolytic HSV engineered to selectively replicate within cancer cells. Cell lines were tested for viral sensitivity to G207 and their ability to support viral replication using standard cytotoxicity and viral replication assays. Eleven of 16 cell lines were moderately to highly sensitive to G207 viral oncolysis. HCC cell lines additionally demonstrated the ability to support viral replication in vitro with as high as 800-fold amplification of the administered viral dose observed. G207 is cytotoxic to, and efficiently replicates within, HCC cell lines in vitro. From these data, we suggest that oncolytic HSV therapy may have ...Continue Reading

Citations

Oct 20, 2006·Expert Opinion on Biological Therapy·Christopher Y WooMichael A Morse
Jun 14, 2008·Expert Opinion on Investigational Drugs·Kaitlyn J KellyYuman Fong
Jun 12, 2010·The Journal of Surgical Research·Joyce WongYuman Fong
Apr 1, 2008·Surgical Oncology Clinics of North America·Travis KidnerYuman Fong
Oct 18, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G Al-MassaraniL Camoin-Jau
Feb 26, 2015·The Journal of General Virology·Adel H JebarStephen Griffin
Feb 20, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jingjing SongXiaoming Yang
Oct 13, 2006·World Journal of Gastroenterology : WJG·Ruben Hernandez-AlcocebaJesus Prieto

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