Oncolytic Recombinant Vesicular Stomatitis Virus (VSV) Is Nonpathogenic and Nontransmissible in Pigs, a Natural Host of VSV

Human Gene Therapy. Clinical Development
Lauro Velazquez-SalinasLuis L Rodriguez

Abstract

Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus that naturally causes disease in livestock including horses, cattle and pigs. The two main identified VSV serotypes are New Jersey (VSNJV) and Indiana (VSIV). VSV is a rapidly replicating, potently immunogenic virus that has been engineered to develop novel oncolytic therapies for cancer treatment. Swine are a natural host for VSV and provide a relevant and well-established model, amenable to biological sampling to monitor virus shedding and neutralizing antibodies. Previous reports have documented the pathogenicity and transmissibility of wild-type isolates and recombinant strains of VSIV and VSNJV using the swine model. Oncolytic VSV engineered to express interferon-beta (IFNβ) and the sodium iodide symporter (NIS), VSV-IFNβ-NIS, has been shown to be a potent new therapeutic agent inducing rapid and durable tumor remission following systemic therapy in preclinical mouse models. VSV-IFNβ-NIS is currently undergoing clinical evaluation for the treatment of advanced cancer in human and canine patients. To support clinical studies and comprehensively assess the risk of transmission to susceptible species, we tested the pathogenicity and transmissibility of oncolyti...Continue Reading

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Citations

Nov 17, 2017·The Journal of General Virology·Sébastien A Felt, Valery Z Grdzelishvili
Apr 11, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Muhammad P JohanNobuo Adachi
Jun 22, 2019·Microbiology Resource Announcements·Lauro Velazquez-SalinasLuis L Rodriguez
Dec 16, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Madhuri Ramji Jaiswal, Pravin Popatrao Kale
Nov 20, 2020·International Journal of Molecular Sciences·June Kyu HwangChae-Ok Yun
May 14, 2021·Molecular Therapy Oncolytics·Susanna C ConcilioKah-Whye Peng
Jul 13, 2021·JCO Precision Oncology·Omeed MoavenMitesh J Borad

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Methods Mentioned

BETA
PCR
ELISA

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