Oncolytic virotherapy for renal cell carcinoma: a novel treatment paradigm?

Expert Opinion on Biological Therapy
Keith A Lawson, Don G Morris

Abstract

Despite the development of novel targeted therapies, metastatic renal cell carcinoma (mRCC) remains an incurable disease. The known responsiveness of mRCC to immunotherapy and the molecular aberrations characteristic of this disease make it an attractive malignancy for treatment with oncolytic viruses (OVs), as these agents are capable of usurping common oncogenic signaling pathways and generating anti-tumor immune responses. The current evidence to support the use of oncolytic virotherapy against mRCC is discussed with emphasis on the molecular and immunological features of this disease that may be exploited by these biologic agents. Furthermore, the mRCC tumor microenvironment will be detailed to highlight the many OV restrictive factors that exist, which will need to be overcome to realize the full potential of oncolytic virotherapy for this disease. Preclinical development of OVs for the treatment of mRCC should utilize syngeneic immunocompetent animal models to allow for the assessment of both the anti-viral and anti-tumor immune response generated by these agents in addition to human xenograft models. Furthermore, rationale combination therapies incorporating currently approved mRCC-targeted therapies should be explored a...Continue Reading

References

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·S ArakawaS Arakawa
Nov 22, 1968·Science·J E Craighead, M F McLane
May 1, 1994·Nature Genetics·J R GnarraF M Duh
Dec 9, 1997·The Journal of Pathology·G KovacsB Zbar
Nov 13, 1998·Science·M C CoffeyP W Lee
Jan 10, 2001·International Journal of Cancer. Journal International Du Cancer·L LusiniP Di Simplicio
Jun 28, 2002·Urological Research·Axel HegeleRainer Hofmann
Sep 5, 2002·Nature Reviews. Cancer·William G Kaelin
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfred E ChangBruce G Redman
May 4, 2004·Trends in Molecular Medicine·Brian D LichtyJohn C Bell
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni C CesanaHoward L Kaufman
May 19, 2006·Cancer Research·Carole SourbierThierry Massfelder
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giulia FulciE Antonio Chiocca
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Augusto C OchoaPaulo C Rodriguez
Jun 21, 2007·Molecular Cancer Research : MCR·Paxton V DicksonAndrew M Davidoff
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paxton V DicksonAndrew M Davidoff
Oct 17, 2007·Molecular Cancer Therapeutics·Kilian GuseAkseli Hemminki
Apr 24, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Timothy KottkeRichard G Vile
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevJohannes Vieweg
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min ZhangJohn Y Kao
Oct 18, 2008·Expert Review of Anticancer Therapy·Robin J PrestwichFiona Errington

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Citations

Mar 23, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru TaguchiTomoki Todo
May 25, 2016·Nature Reviews. Urology·Zahid DelwarWilliam Jia

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