Oncolytic Virus-Based Immunotherapies for Hepatocellular Carcinoma

Mediators of Inflammation
So Young YooJeong Heo

Abstract

Hepatocellular carcinoma is highly refractory cancer which is resistant to conventional chemotherapy and radiotherapy, carrying a dismal prognosis. Although many anticancer drugs have been developed for treating HCC, sorafenib is the only effective treatment, but it only prolongs survival duration for about 3 months. Recently, oncolytic virotherapy has shown promising results in treating HCCs and the effects can be more enhanced by adopting immune modulatory molecules. This review discusses the current status of treating HCC and the effective strategy of oncolytic virus-based immunotherapy for the treatment of HCCs.

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Citations

Nov 14, 2019·Cancers·So Young YooDae-Hwan Kang
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Shima GhavimiNikolaos T Pyrsopoulos
Mar 27, 2019·International Journal of Molecular Sciences·Isabella LurjeGeorg Lurje
Jan 2, 2020·Cancers·Marc HilmiCindy Neuzillet
Dec 4, 2020·Critical Reviews in Oncology/hematology·Eleonora LaiMario Scartozzi
Aug 18, 2021·Expert Review of Gastroenterology & Hepatology·Shubham GuptaTamara Gall
Dec 26, 2021·Cancer Medicine·Justin K H LiuAdel Samson

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Methods Mentioned

BETA
xenografts
xenograft

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