PMID: 26319388Sep 1, 2015Paper

Oncolytic viruses as a new way of treatment of neoplastic diseases

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Urszula KuklaBogusław Okopień

Abstract

Despite the unceasing progression in chemotherapy, radiotherapy and surgery, neoplasms are still the second, after cardiovascular diseases, cause of death in the world. The creation of oncolytic viruses gives hope for increase of anticancer therapy effectiveness. Oncolytic viruses are the type of viruses that selectively infect and cause the lyse of tumor cells excluding normal cells. This mechanism allows to avoid the consequences of the possible replication of the virus, which having entered to the organism, replicates in organism's cells by using the DNA of host cells. The development of genetic engineering and molecular biology has enabled the creation of this kind of genetically modified viruses, which deprive them of their virulence. Currently, there are many clinical trials in progress including the use of oncolytic viruses in head and neck squamous cell carcinoma, thyroid cancer, colorectal cancer, liver cancer, melanoma and glioblastoma multiforme treatment. There are parallel studies in animals using the subsequent viruses. Oncolytic viruses treatment is generally well tolerated, without significant side effects. It is worth to point out that this method combined with chemotherapy and radiotherapy allows to reduce the...Continue Reading

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Related Papers

Expert Review of Anticancer Therapy
Jennifer L CutterBalveen Kaur
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
John Bryan Lott
Critical Reviews in Oncology/hematology
Artrish JeffersonAbigail Hielscher
Journal of Experimental & Clinical Cancer Research : CR
Mingxu GuanEarl E Henderson
© 2021 Meta ULC. All rights reserved